Hydrogel compositions with an erodible backing member
View Patent ↗A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer, a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer. The composition also includes a backing member. Active ingredients, such as a whitening agent, may be included. The composition finds utility as an oral dressing, for example, a tooth whitening composition that is applied to the teeth in need of whitening. The composition can be designed to be removed when the degree of whitening has been achieved or left in place and allowed to erode entirely. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.
1. A composition, comprising:
(a) a hydrogel comprising:
(i) a water-swellable, water-insoluble acrylate polymer which is a copolymer of methacrylic acid and methyl methacrylate and is insoluble in aqueous fluid having a pH of 5.5 or below;
(ii) a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer; and
(iii) an active agent; and
(b) a backing member comprising a material selected from acrylate polymers, starches, alginic acid, alginates, polyamino acids, and combinations thereof, wherein said backing member erodes in a moist environment at a slower rate than the hydrogel.
2. A composition, comprising:
(a) a hydrogel comprising:
(i) a water-swellable, water-insoluble cellulose ester polymer which renders the hydrogel tacky prior to application to a moist surface, but nontacky upon absorption of water;
(ii) a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer; and
(iii) an active agent; and
(b) a backing member that erodes in a moist environment at a slower rate than the hydrogel.
3. A composition, comprising:
(a) a hydrogel comprising:
(i) a water-swellable alginic acid polymer which is insoluble in aqueous fluid having a pH of 5.5 or below;
(ii) a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer; and
(iii) an active agent; and
(b) a backing member that erodes in a moist environment at a slower rate than the hydrogel.
4. A method for whitening teeth while minimizing tooth sensitivity, wherein said method comprises applying to teeth a composition comprising:
(a) a hydrogel comprising:
(i) a water-swellable, water-insoluble acrylate polymer which is a copolymer of methacrylic acid and methyl methacrylate and is insoluble in aqueous fluid having a pH of 5.5 or below;
(ii) a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer; and
(iii) an active agent; and
(b) a backing member comprising a material selected from acrylate polymers, starches, alginic acid, alginates, polyamino acids, and combinations thereof, wherein said backing member erodes in a moist environment at a slower rate than the hydrogel.
5. A method for whitening teeth while minimizing tooth sensitivity, wherein said method comprises applying to teeth a composition comprising:
(a) a hydrogel comprising:
(i) a water-swellable, water-insoluble cellulose ester polymer which renders the hydrogel tacky prior to application to a moist surface, but nontacky upon absorption of water;
(ii) a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer; and
(iii) an active agent; and
(b) a backing member that erodes in a moist environment at a slower rate than the hydrogel.
6. A method for whitening teeth while minimizing tooth sensitivity, wherein said method comprises applying to teeth a composition comprising:
(a) a hydrogel comprising:
(i) a water-swellable alginic acid polymer which is insoluble in aqueous fluid having a pH of 5.5 or below;
(ii) a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer; and
(iii) an active agent; and
(b) a backing member that erodes in a moist environment at a slower rate than the hydrogel.