Sanitizer compositions comprising alcohol and an antimicrobial efficacy enhancer
View Patent ↗The present invention provides alcohol-based sanitizers containing an efficacy enhancer for improved antimicrobial effectiveness. The present invention further provides skin sanitization methods comprising contacting skin having microbial contamination with an antimicrobial composition comprising an alcohol and an efficacy enhancer to achieve a minimum 3 log 10 reduction in skin pathogen contamination after one application.
1. An antimicrobial composition comprising:
(a) from about 50% by weight to about 95% by weight of at least one C 1-6 alcohol; and
(b) from about 0.1% by weight to about 5% by weight of an efficacy enhancer comprising
a monoglyceride of formula (1), formula (2) or a combination thereof
wherein R 1 is a C 5-23 straight or branched chain hydrocarbyl or substituted hydrocarbyl.
2. The antimicrobial composition of claim 1 wherein the alcohol is selected from the group consisting of ethanol, isopropanol, and mixtures thereof, and the alcohol concentration is from about 60% to about 75% by weight.
3. The antimicrobial composition of claim 1 wherein the efficacy enhancer predominantly comprises a monoglyceride of formula (1) or formula (2) wherein R 1 is selected from a C 7-15 straight or branched chain hydrocarbyl, and wherein the monoglyceride concentration is from about 0.1% to about 3% by weight.
4. The antimicrobial composition of claim 1 wherein the composition further comprises a thickener and the composition has a viscosity of from about 2,000 to about 20,000 mPa·s.
5. The antimicrobial composition of claim 1 wherein the composition is capable of providing a log 10 reduction in skin pathogen contamination after ten applications that is greater than the log 10 reduction in skin pathogen contamination after one application as measured by ASTM Method E-2755-10 protocol.
6. The antimicrobial composition of claim 1 wherein the composition is capable of providing a minimum 3 log 10 reduction in skin pathogen contamination after one application and after ten applications as measured by ASTM Method E-2755-10 protocol.
7. The antimicrobial composition of claim 6 wherein the composition is capable of achieving the log 10 reduction in skin pathogen concentration in a contact time of less than one minute.
8. The antimicrobial composition of claim 1 wherein the composition comprising the combination of alcohol and efficacy enhancer is capable of providing greater pathogen kill efficacy as compared to an expected pathogen kill efficacy calculated from (i) the pathogen kill efficacy for a first reference composition not comprising an efficacy enhancer but otherwise having the same ingredients and alcohol concentration as the antimicrobial composition comprising the combination of alcohol and efficacy enhancer and (ii) the pathogen kill efficacy for a second reference composition not comprising alcohol but otherwise having the same ingredients and efficacy enhancer concentration as the antimicrobial composition comprising the combination of alcohol and efficacy enhancer.
9. A skin sanitization method, the method comprising contacting skin having microbial contamination with an antimicrobial composition comprising:
(a) from about 50% by weight to about 95% by weight of at least one C 1-6 alcohol; and
(b) from about 0.1% by weight to about 5% by weight of an efficacy enhancer comprising
a monoglyceride of formula (1), formula (2) or a combination thereof
wherein R 1 is a C 5-23 straight or branched chain hydrocarbyl or substituted hydrocarbyl,
wherein the antimicrobial composition provides a minimum 3 log 10 reduction in skin pathogen contamination after one application as measured by ASTM Method E-2755-10 protocol.
10. The method of claim 9 wherein the alcohol is selected from the group consisting of ethanol, isopropanol, and mixtures thereof, and the alcohol concentration is from about 60% to about 75% by weight.
11. The method of claim 9 wherein the efficacy enhancer predominantly comprises a monoglyceride of formula (1) or formula (2) wherein R 1 is selected from a C 7-15 straight or branched chain hydrocarbyl, and wherein the monoglyceride concentration is from about 0.1% to about 3% by weight.
12. The method of claim 9 wherein the composition further comprises a thickener and the composition has a viscosity of from about 2,000 to about 20,000 mPa·s.
13. The method of claim 9 wherein the composition provides a log 10 reduction in skin pathogen contamination after ten applications that is greater than the log 10 reduction in skin pathogen contamination after one application.
14. The method of claim 9 wherein the composition provides a minimum 3 log 10 reduction in skin pathogen contamination after ten applications.
15. The method of claim 9 wherein the log 10 reduction in skin pathogen concentration is achieved in a contact time of less than one minute.
16. The method of claim 9 wherein the composition comprising the combination of alcohol and efficacy enhancer provides greater pathogen kill efficacy as compared to an expected pathogen kill efficacy calculated from (i) the pathogen kill efficacy for a first reference composition not comprising an efficacy enhancer but otherwise having the same ingredients and alcohol concentration as the antimicrobial composition comprising the combination of alcohol and efficacy enhancer and (ii) the pathogen kill efficacy for a second reference composition not comprising alcohol but otherwise having the same ingredients and efficacy enhancer concentration as the antimicrobial composition comprising the combination of alcohol and efficacy enhancer.