Stimulation method for treatment of ocular conditions
One aspect of the present disclosure relates to a method for modulating, suppressing or preventing an ocular disorder in a subject. One step of the method can include positioning at least one electrode on or proximate to at least one of a sphenopalatine ganglion (SPG), a sphenopalatine nerve (SN), a vidian nerve (VN), a greater petrosal nerve (GPN), a deep petrosal nerve (DPN), or a branch thereof, of the subject. Next, the at least one electrode can be activated to apply an electrical signal to at least one of the SPG, the SN, the VN, the GPN, the DPN, or the branch thereof.
1. A method for modulating, suppressing or preventing an ocular disorder in a subject, the method comprising the steps of:
receiving at least one electrode on or proximate to at least one of a sphenopalatine ganglion (SPG), a sphenopalatine nerve (SN), a vidian nerve (VN), a greater petrosal nerve (GPN), a deep petrosal nerve (DPN), or a branch thereof, of the subject; and
activating the at least one electrode, wherein the at least one electrode is configured to apply an electrical signal to at least one of the SPG, the SN, the VN, the GPN, the DPN, or the branch thereof to modulate, suppress or prevent the ocular disorder, the electrical signal having a frequency of about 1 to 1000 Hz, a pulse-width of about 0.04 to 2 ms, a current of about 0.05 to 100 mA, and a voltage of about 1 to 10 V; wherein the ocular disorder is mediated by autonomic or neurological dysfunction.
2. The method of claim 1 , wherein the electrical signal disrupts nerve signal generation in, or transmission through, at least one of the SPG, the SN, the VN, the GPN, the DPN, or the branch thereof.
3. The method of claim 1 , wherein the at least one electrode is received without penetrating the cranium, into the pterygopalatine fossa so that the at least one electrode is positioned on or proximate to at least one of the SPG, the SN, the VN, or the branch thereof.
4. The method of claim 1 , wherein the activating step generates heat insufficient to cause a lesion on at least one of the SPG, the SN, the VN, the GPN, the DPN, or the branch thereof.
5. The method of claim 1 , further including the step of adjusting the electrical signal without requiring an invasive procedure on the subject.
6. The method of claim 1 , wherein the at least one electrode is received proximate to the GPN, the DPN, or a branch thereof, via an intravascular route.
7. A method for modulating, suppressing or preventing a tearing disorder in a subject, the method comprising the steps of:
receiving at least one electrode on or proximate to at least one of a SPG, a SN, a VN, a GPN, a DPN, or a branch thereof, of the subject; and
activating the at least one electrode wherein the at least one electrode is configured to apply an electrical signal to at least one of the SPG, the SN, the VN, the GPN, the DPN, or the branch thereof to modulate, suppress or prevent the tearing disorder, the electrical signal having a frequency of about 1 to 1000 Hz, a pulse-width of about 0.04 to 2 ms, a current of about 0.05 to 100 mA, and a voltage of about 1 to 10 V; wherein the tearing disorder is mediated by autonomic or neurological dysfunction.
8. The method of claim 7 , wherein the at least one electrode is received without penetrating the cranium, into the pterygopalatine fossa so that the at least one electrode is positioned on or proximate to at least one of the SPG, the SN, the VN, or the branch thereof.
9. The method of claim 7 , wherein the activating step generates heat insufficient to cause a lesion on at least one of the SPG, the SN, the VN, the GPN, the DPN, or the branch thereof.
10. The method of claim 7 , further including the step of adjusting the electrical signal without requiring an invasive procedure on the subject.
11. The method of claim 7 , wherein the at least one electrode is received proximate to the GPN, the DPN, or a branch thereof, via an intravascular route.
12. A method for modulating, suppressing or preventing a dry eye syndrome in a subject, the method comprising the steps of:
receiving at least one electrode on or proximate to at least one of a SPG, a SN, a VN, a GPN, a DPN, or a branch thereof, of the subject; and
activating the at least one electrode, wherein the at least one electrode is configured to apply an electrical signal to at least one of the SPG, the SN, the VN, the GPN, the DPN, or the branch thereof to modulate, suppress, or prevent the dry eye syndrome, the electrical signal having a frequency of about 1 to 1000 Hz, a pulse-width of about 0.04 to 2 ms, a current of about 0.05 to 100 mA, and a voltage of about 1 to 10 V; wherein the dry eye syndrome is mediated by autonomic or neurological dysfunction.
13. The method of claim 12 , wherein the electrical signal disrupts nerve signal generation in, or transmission through, at least one of the SPG, the SN, the VN, the GPN, the DPN, or the branch thereof.
14. The method of claim 12 , wherein the at least one electrode is received without penetrating the cranium, into the pterygopalatine fossa so that the at least one electrode is positioned on or proximate to at least one of the SPG, the SN, the VN, or the branch thereof.
15. The method of claim 12 , wherein the at least one electrode is received proximate to the GPN, the DPN, or a branch thereof, via an intravascular route.