Medicated particulate animal feed supplements and methods of preparation
View Patent ↗The present invention is a process and the product produced by that process for solid, particulate animal feed premixes, characterized by having a certain particle size range, physical stability, hardness range, and rapid dissolution, wherein the premixes contain various drugs and other, pharmaceutically and nutritionally acceptable diluents, binders and formulation aids as needed, or desired.
1. A particulate animal feed supplement, comprising particles having a nominal particle size of from 1800 μm to 50 μm, wherein the particles comprise rice hulls, calcium carbonate and oxytetracycline.
2. A particulate animal feed supplement prepared by the process comprising the steps of:
forming a composition comprising rice hulls and calcium carbonate;
adding oxytetracycline to the composition to form a mixture;
mixing until the mixture is uniform;
compacting the mixture to form a solid material;
milling the solid material to form particles; and
screening the particles to obtain particles having a particle size from 1000 μm to 50 μm.
3. The supplement of claim 2 wherein the rice hulls are present in an amount of from about 2% to about 25% by weight of the supplement.
4. The supplement of claim 2 wherein the calcium carbonate is present in an amount of from about 10% to about 80% by weight of the supplement.
5. The supplement of claim 2 wherein the oxytetracycline is present in an amount of from about 1% to about 60% by weight of the supplement.
6. The supplement of claim 2 further comprising an anti-dusting agent.
7. The supplement of claim 6 wherein the anti-dusting agent is selected from the group consisting of mineral oil, soybean oil and a combination thereof.
8. The supplement of claim 6 , wherein the anti-dusting agent is present in an amount of from greater than 0% to 10% by weight of the supplement.
9. The supplement of claim 6 wherein the anti-dusting agent is present in an amount of from about 1% to about 7% by weight of the supplement.
10. The particulate animal feed supplement of claim 2 , wherein the oxytetracycline is added to the mixture while mixing.
11. A particulate animal feed supplement prepared by the process comprising the steps of:
forming a composition comprising rice hulls and calcium carbonate;
adding mineral oil, and oxytetracycline, or a salt, metal complex or hydrate thereof, to the composition simultaneously or in any order to form a mixture;
mixing until the mixture is uniform;
compacting the mixture to form a solid material;
milling the solid material to form particles; and
screening the particles to obtain particles having a particles size from 1000 μm to 50 μm.
12. The supplement of claim 11 wherein the salt comprises an acid addition salt.
13. The supplement of claim 11 wherein the rice hulls are present in an amount of from about 2% to about 25% by weight of the supplement.
14. The supplement of claim 11 wherein the calcium carbonate is present in an amount of from about 10% to about 80% by weight of the supplement.
15. The supplement of claim 11 wherein the oxytetracycline, or salt, metal complex or hydrate thereof, is present in an amount of from about 1% to about 60% by weight of the supplement.
16. The supplement of claim 11 , wherein the mineral oil is present in an amount of from greater than 0% to 10% by weight of the supplement.
17. The supplement of claim 16 wherein the mineral oil is present in an amount of from about 1% to about 7% by weight of the supplement.
18. The supplement of claim 11 , wherein the oxytetracycline, or salt, metal complex or hydrate thereof, is added to the mixture while mixing.
19. A method 23 , comprising:
forming a uniform mixture by adding oxytetracycline to a mixture of rice hulls and calcium carbonate while mixing;
compacting the uniform mixture to form a solid material; and
obtaining particles by milling the solid material and screening, the particles having a size of from 1800 μm to 50 μm.