Stability in Vitamin and Mineral Supplements
The invention provides a multivitamin and mineral nutritional supplement composition comprising at least one polyvalent metal and at least one oxidizable vitamin with substantially improved resistance to reactions that lead to darkening and/or spotting and reactions that may reduce the potency of oxidizable vitamins. The composition is a multivitamin and mineral composition comprising at least one polyvalent metal and at least one oxidizable vitamin wherein the composition is substantially free of mobile bound water. The invention also includes methods for making such a composition and methods of preventing or reducing oxidation, improving the stability of oxidizable vitamins, and stabilizing the disintegration time of a multi-vitamin and mineral nutritional supplement composition.
1 . A multivitamin and mineral composition comprising at least one polyvalent metal and least one oxidizable vitamin, wherein the composition is substantially free of mobile bound water.
2 . The multivitamin and mineral composition of claim 1 , wherein the polyvalent metal is selected from the group consisting of iron, magnesium, zinc, selenium, copper, cobalt, manganese, molybdenum, vanadium, nickel, tin, chromium and combinations thereof.
3 . The multivitamin and mineral composition of claim 1 , wherein the oxidizable vitamin is selected from the group consisting of Vitamin C, Vitamin E, Vitamin A, Vitamin A precursors. Vitamin B6, Vitamin D3, Vitamin K, folic Acid and combinations thereof.
4 . The multivitamin and mineral composition of claim 1 , further comprising anhydrous dicalcium phosphate.
5 . The multivitamin and mineral composition of claim 1 , further comprising a carotinoid.
6 . The multivitamin and mineral composition of claim 1 , wherein the composition is in a solid dosage form.
7 . A multivitamin and mineral composition of claim 6 , wherein the solid dosage form is selected from the group consisting of tablets, caplets, capsules, chewable dosage forms, powder, sachet and combination thereof.
8 . A method for reducing oxidation induced spotting in a in a multivitamin and mineral tablet and for stabilizing disintegration behavior of multivitamin and mineral tablets over time comprising: combining at least one polyvalent metal selected from the group consisting of iron, magnesium, zinc, selenium, copper, cobalt, manganese, molybdenum, vanadium, nickel, tin, chromium and combinations thereof, and at least one oxidizable vitamin selected from the group consisting of Vitamin C, Vitamin E, Vitamin A, Vitamin A precursors, Vitamin B6, Vitamin D3, folic acid and combinations thereof to form a composition, wherein the composition is substantially free of mobile bound water; and forming the composition into tablets.
9 . The method of claim 8 , further comprising combining anhydrous dicalcium phosphate with the at least one polyvalent metal and at least one oxidizable vitamin.
10 . A multivitamin and mineral composition comprising at least 150 mg of elemental calcium per dosage unit, at least one polyvalent metal, and at least one oxidizable vitamin, wherein the composition is substantially free of mobile bound water.
11 . The multivitamin and mineral composition of claim 10 , wherein the polyvalent metal is selected from the group consisting of iron, magnesium, zinc, selenium, copper, cobalt, manganese, molybdenum, vanadium, nickel, tin, chromium and combinations thereof.
12 . The multivitamin and mineral composition of claim 10 , wherein the oxidizable vitamin is selected from the group consisting of Vitamin C, Vitamin E, Vitamin A, Vitamin A precursors, Vitamin B6, Vitamin D3, Vitamin K, folic acid and combinations thereof.
13 . The multivitamin and mineral composition of claim 12 , wherein the oxidizable vitamin is Vitamin C.
14 . The multivitamin and mineral composition of claim 10 , wherein the composition is in a solid dosage form.
15 . The multivitamin and mineral composition of claim 14 , wherein the solid dosage form is selected form the group consisting of tablets, caplets, capsules, chewable dosage forms, powder, sachet and combination thereof.
16 . The multivitamin and mineral composition of claim 15 , wherein the solid dosage form is a tablet.
17 . The multivitamin and mineral composition of claim 10 , wherein the elemental calcium is provided in the form of anhydrous dicalcium phosphate.
18 . The multivitamin and mineral composition of claim 15 , wherein a first portion of the elemental calcium is provided in the form of anhydrous dicalcium phosphate.