Treatment or prevention of hypotension and shock
View Patent ↗The present invention relates to a method for the prevention and treatment of hypotension and shock due to low peripheral resistance, comprising administering to a mammal in need thereof an effective amount of a certain imidazole derivative or pharmaceutically acceptable ester or salt thereof. In addition, the present invention relates to a method for the treatment of cardiopulmonary resuscitation, comprising administering to a mammal in need thereof an effective amount of a certain imidazole derivative or pharmaceutically acceptable ester or salt thereof.
1. A method of increasing blood pressure in a mammal, comprising administering to the mammal in need thereof an effective amount of a compound of formula I:
wherein R is hydrogen or methyl, or a pharmaceutically acceptable ester or salt thereof.
2. The method according to claim 1 , wherein 3-(1H-imidazol-4-ylmethyl)-indan-5-ol is administered.
3. The method according to claim 2 , wherein 3-(1H-imidazol-4-ylmethyl)-indan-5-ol hydrochloride is administered.
4. The method according to claim 1 , wherein the administration is intravenous.
5. The method according to claim 1 , wherein the mammal is a human.
6. The method according to claim 4 , wherein the effective amount administered is about 10-500 μg/mammal.
7. The method according to claim 6 , wherein the effective amount administered is about 30-200 μg/mammal.
8. The method according to claim 2 , wherein the administration is intravenous.
9. The method according to claim 3 , wherein the administration is intravenous.
10. The method according to claim 2 , wherein the mammal is a human.
11. The method according to claim 3 , wherein the mammal is a human.
12. The method according to claim 4 , wherein the mammal is a human.
13. The method according to claim 5 , wherein the effective amount administered is about 10-500 μg/human.
14. The method according to claim 1 , wherein the mammal is in circulatory shock due to low resistance or in cardiac arrest.