Specific diarylhydantoin and diarylthiohydantoin compounds
View Patent ↗Compositions, such as pharmaceutical compositions, comprising specific diarylhydantoin and diarylthiohydantoin compounds, or salts or solvates thereof, are provided. Isolated and purified forms of the compounds are also described, as are unit dosage forms, compositions of substantially pure compound and kits comprising the compounds. The compounds and pharmaceutical compositions thereof may find use in the prevention and/or treatment of a variety of conditions, including prostate cancer, Parkinson's disease, Alzheimer's disease, and others.
1. A method of treating prostate cancer, comprising administering to an individual in need thereof a pharmaceutical composition comprising a unit dosage amount of a compound of the formula I:
wherein X is S or O, and
when X is S then R 1 is OH or NH 2 ; and
when X is O then R 1 is OH, NH 2 or NHMe,
or a pharmaceutically acceptable salt or solvate thereof.
2. The method of claim 1 , wherein X is S and R 1 is OH or NH 2 .
3. The method of claim 1 , wherein X is O and R 1 is OH, NH 2 or NHMe.
4. The method of claim 1 , wherein the compound is
5. The method of claim 1 , wherein the compound is:
6. The method of claim 1 , wherein the compound is:
7. The method of claim 1 , wherein the compound is:
8. The method of claim 1 , wherein the compound is:
9. The method of claim 1 , wherein the pharmaceutical composition is administered orally.
10. A pharmaceutical composition, comprising:
(a) a unit dosage amount of a compound of the formula I:
wherein X is S or O, and
when X is S then R 1 is OH or NH 2 ; and
when X is O then R 1 is OH, NH 2 or NHMe,
or a pharmaceutically acceptable salt or solvate thereof; and
(b) a pharmaceutically acceptable vehicle.
11. The pharmaceutical composition of claim 10 , wherein X is S and R 1 is OH or NH 2 .
12. The pharmaceutical composition of claim 10 , wherein X is O and R 1 is OH, NH 2 or NHMe.
13. The pharmaceutical composition of claim 10 , wherein the compound is
14. The pharmaceutical composition of claim 10 , wherein the compound is:
15. The pharmaceutical composition of claim 10 , wherein the compound is:
16. The pharmaceutical composition of claim 10 , wherein the compound is:
17. The pharmaceutical composition of claim 10 , wherein the compound is: