Porous polymeric formulation prepared using monomer

1. An analyte sensor comprising:

a crosslinked, hydrophilic copolymer in contact with a surface of an electrode; and

an analyte sensing component embedded within the crosslinked, hydrophilic copolymer,

wherein the crosslinked, hydrophilic copolymer consists of:

backbone chains comprising;

first methacrylate-derived units, each having a first hydrophilic side chain;

second methacrylate-derived units, each having a second hydrophilic side chain,

wherein the first hydrophilic side chain and the second hydrophilic side chains are the same or different;

third methacrylate-derived units; and

hydrophilic crosslinks between the third methacrylate-derived units in different backbone chains, wherein the hydrophilic crosslinks comprise poly(alkylene oxide).

2. The sensor according to claim 1 , wherein the side chain of the first methacrylate-derived units comprise one or more hydroxy groups.

3. The sensor according to claim 1 , wherein the first methacrylate-derived units have the structure of formula (Ia):

wherein

X is —O—, —NR′— or —S—;

y is 0-10; and

R 1 is hydrogen, —C 1 -C 12 alkyl, —C 1 -C 12 alkyl-OH, —SiR′ 3 , —C(O)—C 1 -C 12 alkyl, —C 1 -C 12 alkyl-C(O)OR′, wherein R′ is —C 1 -C 12 alkyl.

4. The sensor according to claim 1 , wherein the first methacrylate-derived units have the structure:

5. The sensor according to claim 1 , wherein the second methacrylate-derived units comprise one or more alkylene oxide units.

6. The sensor according to claim 1 , wherein the second methacrylate-derived units have the structure of formula (II):

wherein

Y is —O—, —NR′— or —S—;

R 2 is hydrogen, —C 1 -C 12 alkyl, —SiR′ 3 , —C(O)—C 1 -C 12 alkyl, —C 1 -C 12 alkyl-C(O)OR′, where R′ is hydrogen or —C 1 -C 12 alkyl; and

z is 0-10.

7. The sensor according to claim 1 , wherein the second methacrylate-derived units have the structure of formula: (II):

wherein

Y is —O—, —NR′— or —S—;

R 2 is hydrogen, —C 1 -C 12 alkyl, —SiR′ 3 , —C(O)—C 1 -C 12 alkyl, —C 1 -C 12 alkyl-C(O)OR′, where R′ is hydrogen or —C 1 -C 12 alkyl; and

z is an average value of from 2 to about 250.

8. The sensor according to claim 1 , wherein the hydrophilic crosslinks have the structure of formula (IIIa):

wherein w is 2-10.

9. The sensor according to claim 1 , wherein the hydrophilic crosslinks have the structure of formula (IIIa):

wherein w is an average value of from about 2 to about 250.

10. The sensor according to claim 1 , wherein the analyte sensing component comprises glucose oxidase.

11. The sensor according to claim 1 , wherein the crosslinked, hydrophilic copolymer has a thickness of about 20 μm.

12. The sensor according to claim 1 , wherein

the first methacrylate-derived units are derived from 2-hydroxyethylmethacrylate;

the second methacrylate-derived units have the structure of formula (II):

wherein

Y is —O—, —NR′— or —S—;

R 2 is hydrogen, —C 1 -C 12 alkyl, —SiR′ 3 , —C(O)—C 1 -C 12 alkyl or —C 1 -C 12 alkyl-C(O)OR′, wherein R′ is hydrogen or 13 C 1 -C 12 alkyl; and

z is an average value of from about 10 to about 15;

the hydrophilic crosslinks have the structure of formula (IIIa):

wherein w is 2; and

the analyte sensing component comprises glucose oxidase.