Renal neuromodulation via drugs and neuromodulatory agents and associated systems and methods
Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.
1. A method for treating a human patient diagnosed with hypertension, the method comprising:
intravascularly positioning a catheter within a renal artery of a human patient and proximate to renal nerves of the patient; and
delivering a neuromodulatory agent via the catheter to tissue external to the renal artery and in contact with or adjacent to the renal nerves, wherein the neuromodulatory agent reduces neural traffic along the renal nerves to and/or from a kidney of the patient,
wherein reducing the neural traffic results in a therapeutically beneficial reduction in blood pressure of the patient.
2. The method of claim 1 wherein delivering a neuromodulatory agent via the catheter comprises delivering a neurotoxin.
3. The method of claim 1 wherein delivering a neuromodulatory agent via the catheter comprises delivering botulinum toxin.
4. The method of claim 1 wherein delivering a neuromodulatory agent via the catheter comprises delivering phenol.
5. The method of claim 1 wherein delivering a neuromodulatory agent via the catheter comprises delivering alcohol.
6. The method of claim 1 wherein reducing neural traffic along the renal nerves via the neuromodulatory agent comprises blocking afferent and/or efferent renal nerve activity.
7. The method of claim 1 wherein the catheter comprises an infusion needle at a distal portion of the catheter, and wherein the method further comprises:
passing the infusion needle through a wall of the renal artery to position at least a portion of the infusion needle at an extravascular location in contact with or adjacent to the renal nerves, and
wherein delivering a neuromodulatory agent comprises delivering the neuromodulatory agent via the infusion needle and ablating at least a portion of the renal nerves of the patient.
8. The method of claim 7 wherein the distal portion of the catheter comprises a side port, and wherein intravascularly positioning the catheter within the renal artery comprises positioning the catheter with the infusion needle positioned for delivery via the side port through at least a portion of the wall of the renal artery.
9. The method of claim 7 wherein the distal portion of the catheter further comprises an expandable positioning element, and wherein intravascularly positioning the catheter within the renal artery comprises locating the catheter within the renal artery via the expandable positioning element before passing the infusion needle through the wall of the renal artery.
10. The method of claim 9 wherein the expandable positioning element comprises an inflatable balloon.
11. The method of claim 1 wherein intravascularly positioning the catheter within the renal artery of the patient comprises delivering the catheter to the renal artery via a guidewire.
12. The method of claim 1 , further comprising intravascularly removing the catheter from the patient after delivering the neuromodulatory agent.