METHOD OF TREATING XEROSTOMIA
View Patent ↗An oral care compositon is described for use in the treatment or alleviation of the symptoms of dry mouth comprising polyvinyl pyrrolidone (PVP) or a derivative thereof, an anionic mucoadhesive polymer and an orally acceptable carrier or excipient.
1. A method of treating xerostomia or mouth dryness by administering to a person in need thereof a liquid composition comprising:
(A) ingredients in effective amounts for treating xerostomia or mouth dryness consisting of:
(i) polyvinyl pyrrolidone or a derivative thereof and (ii) an anionic mucoadhesive polymer; and
(B) one or more orally acceptable carriers or excipients selected from the group consisting of: flavoring agents, humectants, binders, sweetening agents, surfactants, preservatives, buffering agents, coloring agents and water.
2. The method of claim 1 , wherein the ingredients in effective amounts for treating xerostomia or mouth dryness consist of: (i) polyvinyl pyrrolidone or a derivative thereof and (ii) an anionic mucoadhesive polymer selected from carboxymethyl cellulose, xanthan gum, and mixtures thereof.
3. The method of claim 1 , wherein the ingredients in effective amounts for treating xerostomia or mouth dryness consist of: (a) polyvinyl pyrrolidone or vinylpyrrolidone/vinylacetate copolymer, or mixtures thereof; and (b) xanthan gum.
4. The method of claim 1 , wherein the one or more orally acceptable carriers or excipients is selected from the group consisting of:
water;
one or more surfactants; and
one or more buffering agents.
5. The method of claim 1 , wherein the polyvinyl pyrrolidone (PVP) or a derivative thereof is vinylpyrrolidone/vinylacetate copolymer.
6. The method of claim 1 , wherein the composition is exclusive of anticalculus agents and abrasive polishing materials.
7. The method of claim 1 wherein the composition is in the form of a mouthwash or mouthspray.
8. The method of claim 1 wherein the PVP or derivative thereof is present in the amount of 0.1 to 20% w/w.
9. The method of claim 1 wherein the anionic mucoadhesive polymer is present in the range 0.02 to 20% w/w.
10. The method of claim 1 wherein the weight ratio of polyvinyl pyrrolidone or a derivative thereof to the anionic mucoadhesive polymer is from 5:1 to 1:1.
11. The method of claim 1 , wherein the anionic mucoadhesive polymer is xanthan gum.
12. The method of claim 1 , wherein the polyvinyl pyrrolidone or derivative thereof is present in the amount of 0.1 to 20% by weight; and the ratio of the polyvinyl pyrrolidone or derivative thereof to the anionic mucoadhesive polymer is from 4:1 to 2:1.
13. A method of treating xerostomia or mouth dryness by administering to a person in need thereof a liquid composition comprising:
0.1 to 20% by weight polyvinyl pyrrolidone or a derivative thereof; and
an anionic mucoadhesive polymer;
wherein the weight ratio of the polyvinyl pyrrolidone or derivative thereof to the anionic mucoadhesive polymer is from 4:1 to 2:1;
wherein the liquid composition is exclusive of abrasive polishing material.
14. The method of claim 13 , wherein the liquid composition comprises:
0.15 to 4% by weight of the anionic mucoadhesive polymer;
wherein the polyvinyl pyrrolidone or derivative thereof is present in a weight percentage according to the ratio of from 4:1 to 2:1 with the anionic mucoadhesive polymer.
15. The method of claim 14 , wherein the anionic mucoadhesive polymer is xanthan gum.
16. The method of claim 15 , wherein the polyvinyl pyrrolidone or derivative thereof is polyvinyl pyrrolidone,vinylpyrrolidone/vinylacetate copolymer, or mixtures thereof.
17. The method of claim 16 , wherein the polyvinyl pyrrolidone (PVP) or a derivative thereof is vinylpyrrolidone/vinylacetate copolymer.
18. The method of claim 17 , wherein the active ingredients for treating mouth dryness or xerostomia in the composition consist of:
vinylpyrrolidone/vinylacetate copolymer and xanthan gum.
19. A method of treating xerostomia or mouth dryness by administering to a person in need thereof a liquid composition consisting of:
0.1 to 20% by weight polyvinyl pyrrolidone or a derivative thereof;
an anionic mucoadhesive polymer;
one or more orally acceptable carriers or excipients selected from the group consisting of: flavoring agents, humectants, binders, sweetening agents, surfactants, preservatives, buffering agents, coloring agents and water;
optionally, additional ingredients selected from the group consisting of: antimicrobial agents, moisturizing agents, breath freshening agents, and desensitising agents;
wherein the weight ratio of the polyvinyl pyrrolidone or derivative thereof to the anionic mucoadhesive polymer is from 4:1 to 2:1.
20. The method of claim 19 , wherein the polyvinyl pyrrolidone or a derivative thereof is vinylpyrrolidone/vinylacetate copolymer and the anionic mucoadhesive polymer is xanthan gum.