Substituted 6,5-fused bicyclic heteroaryl compounds
View Patent ↗The present invention relates to substituted 6,5-fused bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof.
1. A compound of Formula (IIIa) or a pharmaceutically acceptable salt thereof:
wherein
each of R 1 , R 3 , R 8 , and R 11 is H;
each of R 2 and R 4 is methyl;
R 6 is phenyl or pyridinyl, each substituted with one -Q 2 -T 2 , in which Q 2 is a methyl linker and T 2 is morpholinyl, and R 6 is optionally further substituted with methyl or Cl; and
R 7 is cyclopentyl or isopropyl.
2. The compound of claim 1 , wherein R 6 is phenyl substituted with one -Q 2 -T 2 .
3. The compound of claim 1 , wherein R 6 is pyridinyl substituted with one -Q 2 -T 2 .
4. The compound of claim 2 , wherein R 7 is cyclopentyl.
5. The compound of claim 3 , wherein R 7 is cyclopentyl.
6. A compound selected from
and pharmaceutically acceptable salts thereof.
7. The compound
8. A pharmaceutically acceptable salt of
9. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
10. A pharmaceutical composition comprising a compound of claim 6 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
11. A pharmaceutical composition comprising the compound of claim 7 and a pharmaceutically acceptable carrier.
12. A pharmaceutical composition comprising a pharmaceutically acceptable salt of claim 8 and a pharmaceutically acceptable carrier.