Quinuclidine derivatives and medicinal compositions containing the same

1. A pharmaceutical composition comprising:

(i) 3 -(2-hydroxy-2,2-dithien-2-ylacetoxy)-1 -(3 -phenoxypropyl)-1 - azoniabicyclo-[2.2.2]octane or an enantiomer, mixture of enantiomers, or a racemate thereof, wherein an anion X − with a single negative charge is associated with the positive charge of the nitrogen atom; and

(ii) a phosphodiesterase IV inhibitor.

2. The composition of claim 1 further comprising a pharmaceutically acceptable carrier or diluent.

3. The composition of claim 1 wherein the anion X − is chloride, bromide, iodide, sulfate, nitrate, phosphate, acetate, maleate, fumarate, citrate, oxalate, succinate, tartrate, malate, mandelate, methanesulfonate, p-toluenesulfonate, or trifluoroacetate.

4. The composition of claim 1 which is suitable for inhalation.

5. The composition of claim 1 wherein the composition is a liquid inhalant, powder inhalant, or inhalation aerosol.

6. The composition of claim 2 wherein the pharmaceutically acceptable carrier or diluent is lactose.

7. A method for treating chronic obstructive pulmonary disease, chronic bronchitis, bronchial hyperreactivity, asthma, or rhinitis which method comprises administering to a human or animal patient in need of such treatment an effective amount of the composition of claim 1 .

8. The method of claim 7 further comprising administering an effective amount of a steroid.

9. The method of claim 8 further comprising administering an effective amount of a β 2 agonist.

10. The method of claim 7 further comprising administering an effective amount of a β 2 agonist.