IP Library › Granted Patent US 9,469,673
Granted Patent B2
US 9,469,673 · App. 13/939,873 · Granted Oct 18, 2016

Crystaline forms of HCV inhibitor

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Quick Facts
Patent No.
US 9,469,673
App. No.
13/939,873
Granted
Oct 18, 2016
Kind
B2
Abstract

The present invention features crystalline forms of Compound I. In one embodiment, a crystalline form of Compound I has characteristic peaks in the PXRD pattern at values of two theta (° 2θ) of 10.7, 11.6, 12.7, 13.0, 13.2, 13.7, 14.5, 18.7, 19.0, and 19.9 after equilibration at 43% relative humidity.

Claims (14)

1. A crystalline form of Compound I:

wherein, using a copper anode tube and a wavelength of 1.54178 Å, said crystalline form has characteristic peaks in PXRD pattern at values of two theta (° 2θ) of 10.7, 11.6, 12.7, 13.0, 13.2, 13.7, 14.5, 18.7, 19.0, and 19.9.

2. A crystalline form of Compound I:

wherein, using a copper anode tube and a wavelength 1.54178 Å, said crystalline form has characteristic peaks in PXRD pattern at values of two theta (° 2θ) of 10.70, 11.57, 12.75, 13.02, 13.18, 13.66, 14.47, 18.66, 18.96, and 19.94.

3. The crystalline form of claim 1 , wherein said crystalline form has characteristic peaks in PXRD pattern at values of two theta (° 2θ) of 10.5, 10.7, 11.6, 12.7, 13.0, 13.2, 13.7, 14.5, 17.3, 18.7, 19.0, 19.9, 21.9, 23.3, 24.3, 25.2, 25.6, 26.6, 27.2, and 30.0.

4. The crystalline form of claim 2 , wherein said crystalline form has characteristic peaks in PXRD pattern at values of two theta (° 2θ) of 10.54, 10.70, 11.57, 12.75, 13.02, 13.18, 13.66, 14.47, 17.35, 18.66, 18.96, 19.94, 21.90, 23.31, 24.34, 25.19, 25.56, 26.64, 27.24, and 29.95.

5. The crystalline form of claim 1 , wherein said crystalline form has characteristic peaks in PXRD pattern at values of two theta (° 2θ) of 5.8, 10.5, 10.7, 11.6, 12.7, 13.0, 13.2, 13.7, 14.5, 14.9, 17.3, 17.9, 18.7, 19.0, 19.7, 19.9, 20.5, 20.9, 21.4, 21.9, 22.4, 23.0, 23.3, 23.8, 24.3, 25.2, 25.6, 26.6, 27.2, and 30.0.

6. The crystalline form of claim 2 , wherein said crystalline form has characteristic peaks in PXRD pattern at values of two theta (° 2θ) of 5.80, 10.54, 10.70, 11.57, 12.75, 13.02, 13.18, 13.66, 14.47, 14.88, 17.35, 17.92, 18.66, 18.96, 19.69, 19.94, 20.45, 20.86, 21.42, 21.90, 22.41, 22.98, 23.31, 23.84, 24.34, 25.19, 25.56, 26.64, 27.24, and 29.95.

7. The crystalline form of claim 1 , wherein said crystalline form has characteristic PXRD peaks as shown in FIG. 7 .

8. A composition comprising the crystalline form of claim 1 .

9. A process for making a composition comprising Compound I, comprising dissolving the crystalline form of claim 1 in a solvent.

10. The process of claim 9 , wherein said solvent is a hydrophilic polymer, and the crystalline form of claim 1 is dissolved in said polymer using melt extrusion.

11. A process for making the crystalline form of claim 1 , comprising adding crystalline seeds of said crystalline form to a solution comprising Compound I.

12. The process of claim 11 , wherein said seeds are produced from a supersaturated solution of Compound I using a homogenization device and in the presence of crystalline seeds of said crystalline form.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 29, 2013
From: SHEIKH, AHMAD Y.; DIWAN, MOIZ; PAL, AGNES E.; GONG, YUCHUAN; BRACKEMEYER, PAUL J.; ZHANG, GEOFF; WAGAW, SEBLE
To: ABBVIE INC.
Reel/Frame 031110/0363 →