Porous bioresorbable rope shaped wound dressing comprising microparticles and reduced pressure source
View Patent ↗Methods, system and compositions for making and using a bioresorbable linked dressing made of bioresorbable microspheres in various configurations are provided for use in applying reduced pressure to a wound site. The methods include manufacture of a bioresorbable dressing comprising a casing and bioresorbable microspheres in the form of a rope shape. Further, the casing of the dressing comprises pores formed by a porogen system that may be activated by external to the wound or formed in situ within the wound site. The shape of the dressing allows the dressing to be placed into the wound site such that it fills the shape and size of the wound. Embodiments include formation of various rope dressing and their use in conjunction with reduced pressure therapy.
1. A system for applying reduced pressure tissue treatment to a wound site, the system comprising:
a dressing that is porous bioresorbable and comprising a rope shaped casing having microparticles inside the casing that are bioresorbable, constrictions at repeating intervals of the rope shaped casing, and having a porogen system in the casing adapted to form pores in the casing, the dressing adapted to be disposed adjacent the wound site;
a drape adapted to cover the dressing and create a sealed space containing the dressing;
a reduced pressure source adapted to supply reduced pressure; and
a reduced pressure delivery tube adapted to be fluidly coupled between the reduced pressure source and the dressing to provide the reduced pressure to the dressing.
2. The system of claim 1 , further comprising a distribution manifold fluidly coupled to the reduced pressure delivery tube to distribute the reduced pressure.
3. The system of claim 2 , wherein the distribution manifold compresses the dressing against the wound site.
4. The system of claim 1 , wherein the casing comprises a substantially cylindrical shape.
5. The system of claim 1 , wherein the casing comprises a substantially cylindrical shape and the microparticles are disposed within the casing.
6. The system of claim 1 , wherein the porogen system forms the pores in the casing in response to contact with a fluid.
7. The system of claim 6 , wherein the fluid comprises a body fluid.
8. The system of claim 6 , wherein the fluid comprises water.
9. The system of claim 1 , wherein the porogen system comprises sodium carbonate and an acid.
10. The system of claim 1 , wherein the porogen system comprises a salt.
11. The system of claim 1 , wherein a size of the microparticles is between about 400 and about 600 microns.
12. The system of claim 1 , wherein the microparticles comprise a PLA:PCL (poly(lactide):polycaprolactone) copolymer.
13. The system of claim 12 , wherein the ratio of PLA:PCL is about 90:10.
14. The system of claim 12 , wherein the ratio of PLA:PCL is about 80:20.
15. The system of claim 1 , wherein the microparticles comprise microspheres.
16. The system of claim 1 , wherein the casing has a porosity between about 50% and about 90%.
17. The system of claim 1 , wherein the casing has a porosity greater than about 70%.
18. The system of claim 1 , wherein the casing has a porosity of about 50%.
19. The system of claim 1 , wherein a diameter of the pores of the casing is between about 100 microns and about 500 microns.
20. The system of claim 1 , wherein a size of the microparticles is greater than a diameter of the pores.
21. The system of claim 1 , wherein the casing further comprises a plasticizer.
22. The system of claim 1 , wherein the dressing comprises a first dressing, the system further comprising a second dressing twisted together with the first dressing.
23. The system of claim 1 , wherein the dressing comprises a first dressing, the system further comprises a second dressing braided together with the first dressing.