COMPOSITIONS AND METHODS OF USING (R)-PRAMIPEXOLE
Pharmaceutical compositions of (R)-pramipexole and methods and kits of using such compositions for the treatment of neurodegenerative diseases, or those related to mitochondrial dysfunction or increased oxidative stress are disclosed.
1 . A single dose composition comprising at least about 25 milligrams of (R)-pramipexole; less than about 1.5 milligrams of (S)-pramipexole and a pharmaceutically acceptable carrier.
2 . A pharmaceutical composition comprising from about 25 milligrams to about 5,000 milligrams of (R)-pramipexole, said composition having therapeutic neuroprotective effects and a no adverse effect level attributable to either the (R)-pramipexole or any (S) pramipexole.
3 . A starting daily dose of (R)-pramipexole, comprising at least about 25 milligrams of (R)-pramipexole in a pharmaceutical composition.
4 . A method of treating an acute disease in a patient in need thereof, comprising administering to said patient a daily dose amount of about 25 milligrams to about 5,000 milligrams of (R)-pramipexole in a pharmaceutical composition.
5 . A method of treating a chronic disorder in a patient in need thereof comprising administering a daily dose of about 25 milligrams to about 5000 milligrams of (R)-pramipexole in a pharmaceutical composition.
6 . A tablet comprising from about 50 milligrams to about 500 milligrams of (R)-pramipexole and a pharmaceutically acceptable carrier.
7 . A tablet comprising from about 100 milligrams to about 500 milligrams of (R)-pramipexole and a pharmaceutically acceptable carrier.
8 . A tablet comprising from about 150 milligrams to about 500 milligrams of (R)-pramipexole and a pharmaceutically acceptable carrier.
9 . A tablet comprising greater than about 168 milligrams and less than about 2000 milligrams of (R)-pramipexole and a pharmaceutically acceptable carrier.
10 . A kit comprising:
one or more pharmaceutical compositions comprising (R)-pramipexole; and
instructions for administering or prescribing said one or more pharmaceutical compositions comprising a direction to administer or prescribe said one or more pharmaceutical compositions in an amount sufficient to result in administration of a starting daily dose of at least about 50 milligrams to about 5,000 milligrams of (R)-pramipexole to a patient.
11 . A method of treating a neurodegenerative disease in a patient in need thereof comprising administering to said patient a starting dose of about 25 milligrams to about 5,000 milligrams of (R)-pramipexole in a pharmaceutical composition.