Pyrimidinediamine kinase inhibitors

1. 6-(2-(2-ethoxy-5-(4-methylpiperazin-1-yl)phenylamino)-5-fluoropyrimidin-4-ylamino)-2H-pyrido[3,2-b][1,4]oxazine-3(4H)-one,

or a solvate, pharmaceutically acceptable salt, or N-oxide thereof.

2. A method of treating a disease or condition, comprising administering to a mammal a therapeutically effective amount of 6-(2-(2-ethoxy-5-(4-methylpiperazin-1-yl)phenylamino)-5-fluoropyrimidin-4-ylamino)-2H-pyrido[3,2-b][1,4]oxazine-3(4H)-one,

or a solvate, pharmaceutically acceptable salt, or N-oxide thereof, wherein the disease or condition is ductal carcinoma, invasive lobular carcinoma, lobular carcinoma in situ, metastatic breast cancer, basal cell carcinoma, squamous cell carcinoma, malignant melanoma, Kaposi's sarcoma, small cell lung carcinoma, non-small cell lung carcinoma, bronchial adenoma, pleuropulmonary blastoma, malignant mesothelioma, brain stem glioma, hyptothalamic glioma, cerebellar astrocytoma, cerebral astrocytoma, medullablastoma, ependymal tumors, oligodendroglial, meningiomas, neuroectodermal tumor, pineal tumor, prostate cancer, testicular cancer, penile cancer, uterine cancer (endometrial), cervical cancer, ovarian cancer, vaginal cancer, vulval cancer, uterine sarcoma, ovarian germ cell tumor, anal cancer, colon cancer, colorectal cancer, esophageal cancer, gallbladder cancer, stomach (gastric) cancer, pancreatic cancer, pancreatic cancer-Islet cell, rectal cancer, small-intestine cancer, salivary gland cancer, hepatocellular carcinoma, cholangiocarcinoma, mixed hepatocellular cholangiocarcinoma, primary liver cancer, intraocular melanoma, retinoblastoma, rhabdomyosarcoma, laryngeal cancer, hypopharyngeal cancer, nasopharyngeal cancer, oropharyngeal cancers, lip cancer, oral cancer, squamous neck cancer, metastatic paranasal sinus cancer, T cell lymphoma, B cell lymphoma, non-Hodgkin's lymphoma, cutaneous T cell lymphoma, Hodgkin's disease, lymphoma of the central nervous system, acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, chronic myelogenous leukemia, hair cell leukemia, thyroid cancer, thymoma, malignant thymoma, bladder cancer, soft tissue sarcoma, osteosarcoma, malignant fibrous histiocytoma, lymphosarcoma, or rhabdomyosarcoma.

3. A pharmaceutical composition, comprising 6-(2-(2-ethoxy-5-(4-methylpiperazin-1-yl)phenylamino)-5-fluoropyrimidin-4-ylamino)-2H-pyrido [3,2-b][1,4]oxazine-3(4H)-one,

or a solvate, pharmaceutically acceptable salt, or N-oxide thereof.

4. The composition according to claim 3 formulated for topical administration, ocular administration, oral administration, buccal administration, systemic administration, nasal administration, injection administration, transdermal administration, rectal administration, or vaginal administration.

5. The composition according to claim 3 formulated for inhalation or insufflation.

6. The composition according to claim 3 further comprising a suspending agent, a stabilizing agent, a dispersing agent, a buffer, a dextrose solution, a penetrant, a binding agent, a filler, a lubricant, a disintegrant, a wetting agent, a coating agent, a suspending agent, an emulsifying agent, a preservative, a flavoring agent, a coloring agent, a sweetening agent, or combinations thereof.

7. A method for inhibiting an activity of a kinase, comprising contacting the kinase with an effective amount of 6-(2-(2-ethoxy-5-(4-methylpiperazin-1-yl)phenylamino)-5-fluoropyrimidin-4-ylamino)-2H-pyrido[3,2-b][1,4]oxazine-3 (4H)-one,

or a solvate, pharmaceutically acceptable salt or N-oxide thereof.

8. The method according to claim 7 wherein the kinase is a PLK.

9. The method according to claim 7 wherein the kinase is selected from PLK1, PLK2, PLK3 or PLK4.

10. The method according to claim 7 wherein the kinase is PLK1.

11. The method according to claim 7 comprising contacting the kinase in vivo.