Endovascular devices and methods for exploiting intramural space

1. A method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein, the method comprising:

inserting a first intravascular device into the vascular lumen, the first intravascular device having a distal portion with a keying element;

positioning the distal portion of the first intravascular device in the vascular wall;

orienting the distal portion of the first intravascular device toward the vascular lumen; and

orienting a keyed distal portion of a re-entry device with respect to the keying element of the first device such that the re-entry device is oriented toward the vascular lumen;

wherein the keying element of the first intravascular device engages the keyed distal portion of the re-entry device to prevent relative rotation between the first intravascular device and the re-entry device.

2. The method of claim 1 , wherein the distal portion of the first intravascular device includes a radial curve having a radius of curvature that is less than a radius of curvature of the vascular lumen.

3. The method of claim 2 , wherein the keyed distal portion of the re-entry device includes a radial curve having a radius of curvature less than the radius of curvature of the vascular lumen.

4. The method of claim 1 , wherein the distal portion of the first intravascular device includes a radial curve having a radius of curvature approximating a radius of curvature of the vascular lumen.

5. The method of claim 1 , wherein positioning the distal portion of the first intravascular device comprises traversing the occlusion with the distal portion of the first intravascular device, and further comprising penetrating the vascular wall with the re-entry device toward the vascular lumen.

6. The method of claim 1 , wherein the keyed distal portion of the re-entry device includes external surface features configured for engagement with surfaces along an internal lumen of the keying element.

7. The method of claim 1 , wherein the keying element of the first intravascular device includes a non-circular lumen portion and the keyed distal portion of the re-entry device includes a non-circular portion configured to be positioned in the non-circular lumen.

8. The method of claim 1 , further comprising:

advancing the re-entry device relative to the first intravascular device to penetrate the vascular wall with the re-entry device.

9. The method of claim 8 , further comprising:

advancing the re-entry device into the vascular lumen distal of the first intravascular device.

10. A method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein, the method comprising:

inserting an intravascular device into the vascular lumen;

positioning a distal portion of the intravascular device in the vascular wall;

advancing the distal portion of the intravascular device distally within the vascular wall until the distal portion of the intravascular device is located beyond the occlusion;

advancing a re-entry device through a lumen of the intravascular device to penetrate the vascular wall with the re-entry device; and

advancing the re-entry device into the vascular lumen distal of the intravascular device;

wherein the intravascular device includes a keying element mating with a keyed distal portion of the re-entry device to prevent relative rotation between the intravascular device and the re-entry device.

11. The method of claim 10 , wherein the keying element of the intravascular device includes a non-circular lumen portion and the keyed distal portion of the re-entry device includes a non-circular portion configured to be positioned in the non-circular lumen.

12. The method of claim 10 , wherein the intravascular device includes an elongate tubular shaft and an enlarged distal tip secured to the elongate tubular shaft.

13. The method of claim 12 , wherein the elongate tubular shaft defines a circular lumen portion of the lumen of the intravascular device and the enlarged distal tip defines a non-circular lumen portion of the lumen of the intravascular device in communication with the circular lumen portion of the elongate tubular shaft.

14. The method of claim 13 , wherein the keying element of the intravascular device includes the non-circular lumen portion.

15. The method of claim 14 , wherein the keyed distal portion of the re-entry device includes a non-circular portion configured to be positioned in the non-circular lumen.

16. A method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein, the method comprising:

inserting an intravascular device into the vascular lumen;

positioning a distal portion of the intravascular device in the vascular wall;

advancing the distal portion of the intravascular device distally within the vascular wall until the distal portion of the intravascular device is located beyond the occlusion;

mating a keyed distal portion of a re-entry device with a keying element of the intravascular device to prevent relative rotation between the intravascular device and the re-entry device; and

advancing the re-entry device out of the intravascular device to penetrate the vascular wall with the re-entry device with the keyed distal portion of the re-entry device mated with the keying element of the intravascular device.

17. The method of claim 16 , wherein the keying element of the intravascular device includes a non-circular lumen portion and the keyed distal portion of the re-entry device includes a non-circular portion configured to be positioned in the non-circular lumen.

18. The method of claim 16 , wherein rotational movement of the re-entry device relative to the intravascular device is prevented while advancing the re-entry device out of the intravascular device.

19. The method of claim 16 , wherein the intravascular device includes an elongate tubular shaft having a circular lumen portion and a distal tip having a non-circular lumen portion in communication with the circular lumen portion of the elongate tubular shaft.