COMPOSITIONS AND METHODS FOR TREATING KIDNEY DISEASE
The present invention relates to methods and compositions for the prevention and treatment of renal damage. The invention provides protein-based renal therapeutic agents for administration to subjects in order to prevent or treat renal degeneration or damage.
1 - 20 . (canceled)
21 . An isolated antibody that specifically binds to 5, 8, 10, or 15 contiguous amino acids of SEQ ID NO: 171.
22 . The isolated antibody of claim 21 , wherein the antibody specifically binds to 5 contiguous amino acids of SEQ ID NO: 171.
23 . The isolated antibody of claim 21 , wherein the antibody specifically binds to 8 contiguous amino acids of SEQ ID NO: 171.
24 . The isolated antibody of claim 21 , wherein the antibody specifically binds to 10 contiguous amino acids of SEQ ID NO: 171.
25 . The isolated antibody of claim 21 , wherein the antibody specifically binds to 15 contiguous amino acids of SEQ ID NO: 171.
26 . The isolated antibody of claim 22 , wherein the antibody is selected from the group consisting of a monoclonal antibody, a polyclonal antibody, a Fv fragment of an antibody, a Fab fragment of an antibody, a F(ab′) 2 fragment of an antibody, a recombinant single chain Fv fragment (scFv), a diabody, a triabody, and a tetrabody.
27 . The isolated antibody of claim 26 , wherein the antibody is a monoclonal antibody.