IP Library › Patent Application 13950853
Patent Application
App. No. 13/950,853

NOVEL OPIOID ANTAGONISTS

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Quick Facts
Patent No.
US None
App. No.
13/950,853
Abstract

Certain quinolizidine and octahydropyridopyrazine compounds, pharmaceutical compositions, and methods of their use, inter alia, as opioid receptor antagonists are disclosed.

Claims (14)

1 . A compound of formula I:

wherein:

R 1 is —C(═O)NH 2 ;

X is N—C(═O)-aryl;

or a pharmaceutically acceptable salt thereof.

2 . The compound of claim 1 , wherein said aryl is substituted with halo.

3 . The compound of claim 2 , wherein said aryl is substituted with fluoro.

4 . A method for treatinged Parkinson's disease comprising the step of administering a compound of the formula I

wherein:

R 1 is —C(═O)NH 2 ;

X is N—C(═O)-aryl, said aryl substituted with fluoro;

or a pharmaceutically acceptable salt thereof.

or a pharmaceutically acceptable salt thereof to a patient receiving L-dopa.

5 . The method of claim 4 , wherein the compound of formula I is administered as an adjunct to L-dopa for treatment of dyskinesia associated with the L-dopa treatment.