IP Library Granted Patent US 8,715,314
Granted Patent B1
US 8,715,314 · App. 13/953,540 · Granted May 6, 2014

Vascular treatment measurement methods

Inventors: Vallabh Janardhan (Dallas, TX); Vikram Janardhan (Sacramento, CA)
Assignee: Insera Therapeutics, Inc.
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Quick Facts
Patent No.
US 8,715,314
App. No.
13/953,540
Granted
May 6, 2014
Kind
B1
Abstract

Vascular treatment and methods include a plurality of self-expanding bulbs and a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Joints between woven structures and hypotubes include solder. Woven structures include patterns of radiopaque filaments measureable under x-ray. Structures are heat treated to include at least shapes at different temperatures. A catheter includes a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Heat treating systems include a detachable flange. Laser cutting systems include a fluid flow system.

Claims (45)

1. A method of treating a thrombus in a vessel, the method comprising:

measuring a length of the thrombus in the vessel;

advancing a microcatheter in the vessel, wherein advancing the microcatheter includes crossing the thrombus with a distal end of the microcatheter;

inserting a thrombectomy device in a radially compressed state from an introducer sheath into the microcatheter, the thrombectomy device including a textile structure including a plurality of filaments woven to form a plurality of self-expanding bulbs, at least two of the plurality of filaments comprising radiopaque material and configured to form crossing points visible under x-ray, the crossing points configured to provide approximate length measurement of an expanded length of the thrombectomy device;

after inserting the thrombectomy device from the introducer sheath into the microcatheter, advancing the thrombectomy device in the vessel and through the microcatheter proximate to the distal end of the microcatheter, wherein advancing the thrombectomy device includes crossing the thrombus with the distal-most bulb of the plurality of self-expanding bulbs;

after advancing the thrombectomy device, retracting the microcatheter to unsheathe a length of the thrombectomy device, wherein upon being unsheathed from the microcatheter at least some of the plurality of self-expanding bulbs of the elongate support structure of the thrombectomy device self-expand from the radially compressed state to a radially expanded state, wherein retracting the microcatheter is at least until the length of the thrombectomy device is at least as long as the measured length of the thrombus in the vessel;

entrapping the thrombus in the unsheathed self-expanding bulbs;

after entrapping the thrombus in the unsheathed self-expanding bulbs, removing the thrombus from the vessel in substantially one piece using the thrombectomy device;

measuring a length of the thrombus out of the vessel; and

comparing the length of the thrombus in the vessel to the length of the thrombus out of the vessel.

2. The method of claim 1 , further comprising, after retracting the microcatheter, torsionally rasping the thrombectomy device, wherein torsionally rasping the thrombectomy device includes entrapping the thrombus in the unsheathed self-expanding bulbs.

3. The method of claim 1 , wherein the vessel comprises a blood vessel in a brain or a blood vessel in a leg.

4. A method of treating a thrombus in a vessel, the method comprising:

measuring a length of the thrombus in the vessel; and

expanding at least part of a thrombectomy device in the vessel proximate to the thrombus, wherein expanding at least part of the thrombectomy device includes retracting a sheath surrounding the thrombectomy device by a customizable retraction length, the customizable retraction length based at least partially on the measured length of the thrombus in the vessel.

5. The method of claim 4 , wherein measuring the length of the thrombus in the vessel comprises at least one of:

computerized axial tomography (CAT) scan digital imaging measurement;

CAT scan angiogram;

magnetic resonance imaging (MRI) angiogram; and

catheter angiogram.

6. The method of claim 4 , wherein the customizable retraction length is greater than a length of the at least part of the thrombectomy device after expanding.

7. The method of claim 4 , wherein the thrombectomy device comprises a plurality of filaments woven into a textile structure, at least two of the plurality of filaments including radiopaque material configured to form crossing points visible under x-ray, the crossing points configured to provide approximate length measurement of the expanded length of the thrombectomy device.

8. The method of claim 4 , wherein the thrombectomy device includes a plurality of self-expanding bulbs.

9. The method of claim 8 , wherein, after expanding the at least part of the thrombectomy device, at least one of the plurality of self-expanding bulbs is distal to the thrombus.

10. The method of claim 8 , wherein, after expanding the at least part of the thrombectomy device, at least two of plurality of bulbs have different outer diameters.

11. The method of claim 4 , further comprising:

removing the thrombus from the vessel in substantially one piece using the thrombectomy device;

measuring a length of the thrombus out of the vessel; and

comparing the length of the thrombus in the vessel to the length of the thrombus out of the vessel.

12. The method of claim 11 , further comprising, if the length of the thrombus out of the vessel is less than the length of the thrombus in the vessel, removing remaining thrombus from the vessel.

13. The method of claim 11 , wherein measuring the length of the thrombus out of the vessel comprises placing the thrombus proximate to a ruler on a package of the thrombectomy device.

14. The method of claim 4 , wherein the vessel comprises a blood vessel in a brain or a blood vessel in a leg.

15. A method of treating a thrombus in a vessel, the method comprising:

measuring a length of the thrombus in the vessel;

removing the thrombus from the vessel in substantially one piece using a thrombectomy device;

measuring a length of the thrombus out of the vessel; and

comparing the length of the thrombus in the vessel to the length of the thrombus out of the vessel.

16. The method of claim 15 , further comprising, if the length of the thrombus out of the vessel is less than the length of the thrombus in the vessel, removing remaining thrombus from the vessel.

17. The method of claim 15 , wherein measuring the length of the thrombus in the vessel comprises at least one of:

computerized axial tomography (CAT) scan digital imaging measurement;

CAT scan angiogram;

magnetic resonance imaging (MRI) angiogram; and

catheter angiogram.

18. The method of claim 15 , wherein measuring the length of the thrombus out of the vessel comprises placing the thrombus proximate to a ruler on a package of the thrombectomy device.

19. The method of claim 15 , wherein the vessel comprises a blood vessel in a brain or a blood vessel in a leg.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded Sep 9, 2021
From: KNOBBE, MARTENS, OLSON & BEAR, LLP
To: INSERA THERAPEUTICS, INC.
Reel/Frame 057454/0677 →
SECURITY INTEREST Recorded Jun 30, 2020
From: INSERA THERAPEUTICS, INC.
To: KNOBBE, MARTENS, OLSON & BEAR, LLP
Reel/Frame 053095/0350 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 1, 2013
From: JANARDHAN, VALLABH; JANARDHAN, VIKRAM
To: INSERA THERAPEUTICS, INC.
Reel/Frame 030923/0881 →
Continuity (2)
Continuation In Part 13952982 · Jul 29, 2013
Provisional Application 61798540 · Mar 15, 2013