METHODS OF TREATING SUBCHONDRAL BONE TO PREVENT THE PROGRESSION OF OSTEOARTHRITIS IN JOINTS
Methods of therapeutically treating osteoarthritis in a joint are disclosed. These methods aim to prevent the progression of osteoarthritis of a joint by treating the subchondral bone to heal, or delay the onset or progression of, bone marrow edema or lesions in the subchondral bone region of the joint. Associated devices and instruments for such subchondral treatment are also provided.
1 . A method of treating osteoarthritis of a joint, comprising:
accessing a path to a target area near a defect in subchondral bone of the joint; and
introducing a therapeutic agent to the target area through the access path, the therapeutic agent being capable of healing or delaying the progression of the defect;
wherein the step of introducing the therapeutic agent preserves the articular surface of the joint.
2 . The method of claim 1 , wherein the defect is a bone marrow lesion or bone marrow edema.
3 . The method of claim 1 , wherein the therapeutic agent comprises a phosphonate-based drug.
4 . The method of claim 3 , wherein the phosphonate-based drug comprises bisphosphonate.
5 . The method of claim 1 , wherein the therapeutic agent is introduced by direct injection to the target area.
6 . The method of claim 1 , wherein the therapeutic agent is contained in a drug eluting carrier.
7 . The method of claim 1 , wherein the therapeutic agent is contained on an implantable device.
8 . The method of claim 1 , further including the step of mechanically stabilizing the target area with an implantable device.
9 . The method of claim 1 , further including the step of mechanically stabilizing the target area by implanting in the bone, via the access path, an implantable device that structurally supports the subchondral bone.
10 . The method of claim 1 , further including the step of injecting in the subchondral bone, via the access path, a bone hardening material.
11 . The method of claim 10 , wherein the bone hardening material comprises a bone cement, bone void filler, or bone substitute material.
12 . The method of claim 1 , wherein the access path is determined using a guide instrument that provides a set of tool guiding portals for targeting the location of the target area of the subchondral bone.
13 . The method of claim 1 , wherein the access path is determined using a mapping system that provides a set of coordinates for targeting the location of the target area of the subchondral bone.
14 . The method of claim 1 , wherein the access path is determined using a template for targeting the location of the target area of the subchondral bone.
15 . The method of claim 1 , further including the step of compacting bone tissue, via the access path, to create a void in or adjacent to the target area of the subchondral bone.
16 . The method of claim 1 , further including arthroscopically treating the joint.
17 . The method of claim 1 , wherein the joint is a knee, hip, shoulder, ankle, or spine.