Molecular marker for cancer stem cell
View Patent ↗A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
1. A method for treating a DNAJB8 expressing tumor comprising a step of administering an isolated peptide as an active ingredient, wherein the isolated peptide
(i) consists of AFMEAFSSF (SEQ ID NO: 71), or
(ii) consists of AFMEAFSSF (SEQ ID NO: 71) in which the second amino acid from N-terminal is substituted to tyrosine, tryptophan, phenylalanine or methionine and/or the C-terminal amino acid is substituted to leucine, isoleucine, tryptophan, phenylalanine or methionine; and
wherein the isolated peptide has HLA-A24 binding ability.
2. A method according to claim 1 , wherein the isolated peptide consists of AFMEAFSSF (SEQ ID NO: 71).