Haptens of paliperidone
The invention relates to compounds of Formula I, wherein L 1 , L 2 , and L 3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from paliperidone. The invention also relates to conjugates of a paliperidone hapten and a protein.
1. The compound of Formula I
wherein
L 1 is OC(O)(CH 2 ) n , or O(CH 2 ) n ;
wherein n is 1, 2, or 3;
L 2 is NHC(O),
or absent;
L 3 is (CH 2 ) m CO 2 H, or
wherein m is 0-3; provided that m may only be 0 if L 2 is absent, and further provided that when L 2 is absent L 3 is
2. The compound of claim 1 , wherein
L 1 is OC(O)(CH 2 ) n , or O(CH 2 ) n ;
wherein n is 1, 2, or 3;
L 2 is NHC(O),
or absent;
L 3 is (CH 2 ) m CO 2 H, or
wherein m is 0-2; provided that m may only be 0 if L 2 is absent, and further provided that when L 2 is absent L 3 is
3. The compound of claim 1 which is: