Oligomer-dantrolene conjugates and related compounds
View Patent ↗The invention relates to (among other things) oligomer-dantrolene conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered compounds.
1. A compound having the following structure
wherein:
R 2 is a member of the group consisting of hydrogen, hydroxyethyl, alkyl, and 4-pyridylethyl;
(a) is either zero or one;
(b) is either zero or one;
R 3 , when present, is selected from the group consisted of nitro, cyano, amino, chloro, bromo, acetyl, carboxy, methyl and trifluoromethyl;
R 4 , when present, is selected from the group consisting of nitro, cyano, amino, chloro, bromo, acetyl, carboxy, methyl and trifluoromethyl; and
POLY is a poly(ethylene oxide) having a molecular weight of below about 1500 Daltons.
2. The compound of claim 1 , wherein the poly(ethylene oxide) has a number of repeating monomers in the range of from 1 to 30.
3. The compound of claim 1 , wherein the poly(ethylene oxide) includes an alkoxy end-capping moiety.
4. A composition comprising a compound of claim 1 and a pharmaceutically acceptable excipient.
5. A composition of matter comprising a compound of claim 1 , wherein the compound is present in a dosage form.