Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof

1. A method of making (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate-containing pharmaceutical pellets comprising:

mixing the (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate in an aqueous medium to form a wet mass;

adding acetic acid to the wet mass to form a mixture;

maintaining the mixture at a pH at or below 3.8; and

forming pellets.

2. The method of claim 1 , comprising maintaining the mixture at a pH at or below 3.5.

3. The method of claim 1 , wherein the step of mixing further comprising combining a binder to the aqueous medium and the (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate to form the wet massif; and

the step of forming pellets further comprising

extruding the mixture to form an extrudate;

spheronizing the extrudate to form pellets; and

drying the pellets.

4. The method of claim 1 , wherein the step of mixing further comprising combining a binder to the aqueous medium and the (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate to form the wet mass; and

the step of forming pellets further comprising

introducing the mass mixture onto a rotating friction plate to form pellets; and

drying the pellets.