IP Library › Granted Patent US 9,234,885
Granted Patent B2
US 9,234,885 · App. 13/979,179 · Granted Jan 12, 2016

Methods and assays for treating filoviridae infections

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Quick Facts
Patent No.
US 9,234,885
App. No.
13/979,179
Granted
Jan 12, 2016
Kind
B2
Abstract

Methods and assays for treating a subject with a filovirus infection using an agent that inhibits Niemann-Pick CI (NPCI), VPSII, VPSI6, VPSI8, VPS33A, VPS39, VPS41, BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4. Methods for screening for an agent that treats and/or prevents infection of a subject with a filovirus, where the methods comprise determining whether the agent inhibits one or more of Niemann-Pick CI (NPCI), VPSII, VPSI6, VPSI8, VPS33A, VPS39, VPS41. BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4, wherein an agent that inhibits one or more of NPCI, VPSII, VPSI6, VPSI8, VPS33A, VPS39, VPS41, BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4 is a candidate for treating and/or preventing an infection with a filovirus and wherein an agent that does not inhibit NPCI, VPSII, VPSI6, VPSI8, VPS33A. VPS39, VPS41, BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4 is not a candidate for treating and/or preventing an infection with a filovirus.

Claims (9)

1. A method for treating a subject infected with an ebolavirus or a marburgvirus or for preventing an infection with an ebolavirus or a marburgvirus in a subject exposed to an ebolavirus or a marburgvirus comprising administering to the subject an agent that inhibits Niemann-Pick C1 (NPC1) in an amount effective to treat and/or prevent infection with an ebolavirus or a marburgvirus.

2. The method of claim 1 for treating a subject infected with an ebolavirus or a marburgvirus.

3. The method of claim 1 for preventing an infection with an ebolavirus or a marburgvirus in a subject exposed to an ebolavirus or a marburgvirus.

4. The method of claim 3 , wherein the subject is exposed to an ebolavirus or a marburgvirus as the result of bioterrorism or biological warfare.

5. The method of claim 1 , wherein the agent inhibits NPC1 protein activity.

6. The method of claim 1 , wherein the agent inhibits nucleic acid that encodes NPC1 protein.

7. The method of claim 1 , wherein the agent targets domain C of NPC1 or nucleic acid encoding domain C of NPC1.

8. The method of claim 1 , wherein the subject is infected with an ebolavirus or exposed to an ebolavirus.

9. The method of claim 1 , wherein the subject is infected with a marburgvirus or exposed to a marburgvirus.

Assignments (5)
MERGER AND CHANGE OF NAME Recorded Feb 26, 2019
From: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.; ALBERT EINSTEIN COLLEGE OF MEDICINE
To: ALBERT EINSTEIN COLLEGE OF MEDICINE
Reel/Frame 048438/0275 →
CONFIRMATORY LICENSE Recorded May 17, 2017
From: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 042482/0192 →
CORRECTIVE ASSIGNMENT TO CORRECT PATENT NO. 8726046 TO 8729046 PREVIOUSLY RECORDED AT REEL: 036876 FRAME: 0018. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Oct 28, 2015
From: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
To: COM AFFILIATION, INC.
Reel/Frame 036984/0184 →
CHANGE OF NAME Recorded Oct 20, 2015
From: COM AFFILIATION, INC.
To: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
Reel/Frame 036907/0795 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 16, 2015
From: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
To: COM AFFILIATION, INC.
Reel/Frame 036876/0018 →