Chlorhexidine gluconate containing solvent adhesive
View Patent ↗Methods for incorporating chlorhexidine salts into solvent based adhesives are described. The methods involve freeze drying an aqueous solution of the chlorhexidine salt and obtaining the chlorhexidine salt in a particulate form. The dry powder can then be dissolved into an appropriate solvent used with the adhesive of interest. Also described are particles including chlorhexidine salts that are incorporated in adhesives. Also described are various medical products utilizing the adhesive and chlorhexidine compound, and related methods of use.
1. A method of forming an adhesive containing chlorhexidine, the method comprising:
providing an aqueous solution of at least one chlorhexidine salt;
actively drying the aqueous solution to thereby obtain the at least one chlorhexidine salt in solid form;
providing an adhesive component;
providing a solvent compatible with the adhesive component;
solubilising the solid form chlorhexidine in the solvent to form a chlorhexidine solution,
wherein the solid form chlorhexidine is dissolved in the solvent;
combining the chlorhexidine solution with the adhesive component to thereby form an adhesive containing chlorhexidine.
2. The method of claim 1 wherein the aqueous solution contains the at least one chlorhexidine salt in a total concentration by weight of from about 1% to the solubility limit of the at least one chlorhexidine salt.
3. The method of claim 1 wherein the at least one chlorhexidine salt includes chlorhexidine gluconate or chlorhexidine digluconate.
4. The method of claim 3 wherein the concentration of chlorhexidine gluconate or chlorhexidine digluconate in the aqueous solution is one of 20% and 40%.
5. The method of claim 1 wherein actively drying includes at least one of freeze drying and spray drying.
6. The method of claim 5 wherein freeze drying is performed at a temperature within a range of from about −80° C. to about 10° C.
7. The method of claim 6 wherein the temperature is from about −50° C. to about 0° C.
8. The method of claim 7 wherein the temperature is about −20° C.
9. The method of claim 5 wherein freeze drying is performed at a pressure within a range of from about 0.01 bars to about 0.95 bars.
10. The method of claim 9 wherein the pressure is from about 0.10 bars to about 0.50 bars.
11. The method of claim 10 wherein the pressure is about 0.18 bars.
12. The method of claim 1 wherein the solid form is a layer form.
13. The method of claim 1 wherein the solid form is a particulate form.
14. The method of claim 5 wherein freeze drying includes spraying the aqueous solution of at least one chlorhexidine salt.
15. The method of claim 1 wherein the adhesive component is selected from the group consisting of (i) an adhesive ingredient, (ii) an adhesive premix, and (iii) an adhesive formulation.
16. The method of claim 15 wherein the adhesive component is an adhesive formulation.
17. The method of claim 16 wherein the adhesive formulation is selected from the group consisting of acrylic adhesives, rubber adhesives, silicone adhesives, polyurethane adhesives, and combinations thereof.
18. The method of claim 16 wherein the adhesive formulation includes an acrylic adhesive.
19. The method of claim 1 wherein the solvent is methanol.
20. An adhesive containing chlorhexidine produced by the methods of claim 1 .