Human lactoferrin derived peptides and their use
View Patent ↗The present invention relates to new peptides and to use thereof, in particular for treatment and/or prevention of infections, inflammations, pain, wounds, scar and/or tumors.
1. An isolated peptide comprising the amino acid sequence
(SEQ ID NO: 2)
XI-X2-W-X4-X5-X6-M-X8-K-V-X11-X12-X13-X14-X15-
X16-X17
wherein
X1 is F, K or R
X2 is Q, W or R
X4 is K or R
X5 is R or K
X6 is N, A, V, W or R
X8 is R or K
X11 is R, F or K
X12 is G, S, N, V, L or H
X13 is S, G, T or V
X14 is R, L, Y, W or K
X15 is R, K or W
X16 is R, K or W, and
X17 is R, G, Q, V, M, F, W or K;
and wherein the peptide comprises an amino acid sequence selected from the group consisting of:
(SEQ ID: 21)
R-Q-W-K-R-R-M-R-K-V-F-H-S-Y-R-R-M-G,
(SEQ ID: 22)
K-Q-W-K-R-W-M-R-K-V-F-V-S-L-R-R-V-G,
(SEQ ID: 23)
R-Q-W-K-R-V-M-R-K-V-F-G-S-R-W-W-R-G,
(SEQ ID: 24)
K-Q-W-K-R-M-M-R-K-V-F-S-V-R-R-W-F-L,
(SEQ ID: 27)
F-R-Q-W-K-R-W-M-R-K-V-F-H-S-W-R-R-W,
(SEQ ID: 6)
F-Q-W-K-R-R-M-R-K-V-R-G-S-R-R-R-R-G,
(SEQ ID: 7)
W-F-Q-W-K-R-A-M-R-K-V-R-G-S-R-R-R-R-G,
(SEQ ID: 8)
F-W-W-K-R-A-M-R-K-V-R-G-S-R-R-R-R-G,
(SEQ ID: 19)
F-Q-W-K-R-R-M-R-K-V-R-G-S-K-K-K-K-G,
(SEQ ID: 20)
F-Q-W-K-R-R-M-R-K-V-R-G-S-L-R-R-W-G,
(SEQ ID: 25)
F-R-W-K-R-R-M-R-K-V-R-G-S-R-R-R-Q-G,
(SEQ ID: 31)
F-W-W-K-R-A-M-R-K-V-R-L-S-R-R-R-R-G,
(SEQ ID: 32)
F-W-W-K-R-A-M-R-K-V-R-N-S-R-R-R-R-G,
and
(SEQ ID: 34)
F-W-W-K-K-A-M-K-K-V-K-G-T-R-R-R-R-G.
2. The isolated peptide according to claim 1 , comprising CONH 2 at the carboxy terminal end.
3. The isolated peptide according to claim 1 , comprising CH 3 CONH at the amino terminal end.
4. A pharmaceutical composition comprising a peptide according to claim 1 .
5. A food stuff comprising a peptide according to claim 1 .
6. A method of treating bacterial infections, fungal infections, pain, wounds, and scars comprising administering to a patient in need thereof an effective amount of the isolated peptide according to claim 1 .
7. A method of treating bacterial infections, fungal infections, pain, wounds, and scars comprising administering to a patient in need thereof an effective amount of the pharmaceutical composition according to claim 4 .
8. A medicament comprising the isolated peptide according to claim 1 .