Recombinant viral vectors and methods for inducing a heterosubtypic immune response to influenza A viruses

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Quick Facts

Patent No.: US 9,463,237
App. No.: 13/982,524
Granted: Oct 11, 2016
Kind: B2

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Abstract

The present invention relates to recombinant viral vectors and methods of using the recombinant viral vectors to induce an immune response to influenza A viruses. The invention provides recombinant viral vectors based, for example, on the non-replicating modified vaccinia virus Ankara. When administered according to methods of the invention, the recombinant viral vectors are designed to be cross-protective and induce heterosubtypic immunity to influenza A viruses.

Claims (3)

1. A recombinant modified vaccinia virus Ankara (rMVA) comprising a first gene cassette encoding an influenza A headless hemagglutinin (hlHA) polypeptide of SEQ ID NO: 15 and a second gene cassette encoding influenza A nucleoprotein (NP).

2. A pharmaceutical composition comprising the rMVA of claim 1 .

3. A method of inducing a heterosubtypic immune response to influenza A viruses in an individual comprising administering a pharmaceutical composition comprising the rMVA of claim 1 to the individual.

Assignments (10)

CHANGE OF NAME Recorded Nov 20, 2025

From: RESILIENCE GOVERNMENT SERVICES, INC,

To: ALACHUA GOVERNMENT SERVICES, INC.

Reel/Frame 073279/0021 →

CHANGE OF NAME Recorded Sep 8, 2022

From: OLOGY BIOSERVICES, INC.

To: RESILIENCE GOVERNMENT SERVICES, INC.

Reel/Frame 061399/0903 →

RELEASE OF SECURITY INTEREST Recorded Aug 20, 2020

From: MIDCAP FINANCIAL TRUST, AS AGENT

To: OLOGY BIOSERVICES, INC.; NANO ADM, LLC

Reel/Frame 053561/0070 →

CHANGE OF NAME Recorded Jan 23, 2019

From: NANOTHERAPEUTICS, INC.

To: OLOGY BIOSERVICES, INC.

Reel/Frame 049518/0666 →

SECURITY INTEREST Recorded May 1, 2018

From: OLOGY BIOSERVICES, INC.

To: MIDCAP FINANCIAL TRUST, AS AGENT

Reel/Frame 046050/0305 →

CORRECTIVE ASSIGNMENT TO CORRECT THE CORRESPONDENCE DATA PREVIOUSLY RECORDED ON REEL 037155 FRAME 0732. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded May 2, 2016

From: BAXALTA GMBH

To: NANOTHERAPEUTICS, INC.

Reel/Frame 038592/0044 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 24, 2015

From: BAXALTA GMBH

To: NANOTHERAPEUTICS, INC.

Reel/Frame 037155/0732 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 28, 2015

From: BAXTER INTERNATIONAL INC.

To: BAXALTA GMBH

Reel/Frame 036502/0752 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 18, 2015