Granted Patent B2

US 8,895,570 · App. 13/994,321 · Granted Nov 25, 2014

Abstract

Claims (21)

1. A compound

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 in free base form.

3. The pharmaceutically acceptable salt of the compound of claim 2 .

4. A pharmaceutical composition comprising the compound, or pharmaceutically acceptable salt thereof, as claimed in any one of claims 1 to 3 in association with a pharmaceutically acceptable adjuvant, diluent or carrier.

5. The pharmaceutical composition according to claim 4 , wherein the composition is a topical composition.

6. A process for the preparation of a compound of formula (I), or a pharmaceutically acceptable salt thereof, as defined in claim 1 comprising:

(a)

reacting a compound of the formula (II), or a salt thereof:

wherein Lg is a leaving group;

with piperidine; or

(b)

reacting a compound of the formula (III), or a salt thereof:

with methyl (4-formylphenyl)acetate in the presence of a reducing agent;

and thereafter optionally forming a pharmaceutically acceptable salt of a compound of formula (I).

7. A compound of the formula (II), or a salt thereof:

wherein Lg is a leaving group.

8. A compound of the formula (III):

or a salt thereof.

9. A compound of the formula (IV), or a salt thereof:

wherein R 1 is hydrogen or methyl.

Assignments (11)