Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds

1. A conjugate of formula:

wherein:

each R 1 is methyl;

each R 2 is methyl;

each X is —(CH 2 ) m — or —CH 2 C(O)NHCH(R 3 )—;

each m is a positive integer from 1 to about 12;

R 3 is —H; and

each n is a positive integer from 10 to about 400;

or pharmaceutically acceptable salts and solvates thereof;

wherein the conjugate has an increased tumor growth delay compared to cabazitaxel.

2. The conjugate of claim 1 of formula:

or pharmaceutically acceptable salts and solvates thereof.

3. The conjugate of claim 1 of formula:

or pharmaceutically acceptable salts and solvates thereof.

4. The conjugate of claim 1 selected from the group consisting of:

or pharmaceutically acceptable salts of each of the foregoing.

5. A composition comprising a plurality of conjugates, wherein at least 80% of the conjugates in the composition have a structure encompassed by claim 1 .

6. The composition of claim 5 , further comprising a pharmaceutical excipient.

7. The composition of claim 5 , wherein at least 85% of the conjugates in the composition have a structure encompassed by claim 1 .

8. The composition of claim 5 , wherein at least 95% of the conjugates in the composition have a structure encompassed by claim 1 .