Diagnostic drug and diagnostic method for Alzheimer's disease
The present invention provides an agent for determining Alzheimer's disease, comprising an anti-S38AA antibody, a method of determining Alzheimer's disease in a test animal, comprising detecting an S38AA fragment in a sample collected from said animal, and a method of screening for a substance that treats or prevents Alzheimer's disease, comprising contacting a test substance with a cell permitting measurement of production of a S38AA fragment, measuring the production amount of the S38AA fragment in the cell, and comparing the production amount with that of the S38AA fragment in a control cell free of contact with the test substance, and selecting a test substance that down-regulates the production amount of the S38AA fragment as a substance capable of treating or preventing Alzheimer's disease, based on the comparison results.
1. A method of treating a test person affected with Alzheimer's disease or having a high possibility of being affected with Alzheimer's disease in the near future comprising the steps of:
(1) detecting an S38AA fragment with an anti-S38AA antibody in a sample collected from the test person,
(2) comparing the amount of S38AA fragment in the sample collected from the test person with an amount of S38AA fragment in a sample collected from a normal person,
(3) determining the test person is affected with Alzheimer's disease or has a high possibility of being affected with Alzheimer's disease in the near future when the amount of S38AA fragment in the sample from the test person is high relative to the amount of S38AA fragment in the sample from the normal person, and
(4) administering an agent capable of treating or preventing Alzheimer's disease to the test person who is determined to be affected with Alzheimer's disease or has a high possibility of being affected with Alzheimer's disease in the near future in step (3),
wherein the S38AA is a polypeptide comprising the amino acid sequence shown by SEQ ID NO: 2,
wherein the S38AA fragment is a polypeptide consisting of the S38AA extra-membranous domain or a partial polypeptide thereof,
wherein the antibody is an antibody specifically recognizing an amino acid region selected from the following (a) to (c): (a) the 689-1119th amino acids of the amino acid sequence shown by SEQ ID NO: 2, (b) the 399-688th amino acids of the amino acid sequence shown by SEQ ID NO: 2, and (c) an amino acid region spanning both regions (a) and (b), and
wherein the sample collected from the test person and the sample collected from the normal person are blood.
2. A method of starting an early treatment for suppressing the pathological progression by a symptomatic drug therapy for a test person affected with Alzheimer's disease or having a high possibility of being affected with Alzheimer's disease in the near future comprising the steps of:
(1) detecting an S38AA fragment with an anti-S38AA antibody in a sample collected from the test person,
(2) comparing the amount of S38AA fragment in the sample collected from the test person with an amount of S38AA fragment in a sample collected from a normal person,
(3) determining the test person is affected with Alzheimer's disease or has a high possibility of being affected with Alzheimer's disease in the near future when the amount of S38AA fragment in the sample from the test person is high relative to the amount of S38AA fragment in the sample from the normal person, and
(4) administering the symptomatic drug to the test person who is determined to be affected with Alzheimer's disease or has a high possibility of being affected with Alzheimer's disease in the near future in step (3),
wherein the S38AA is a polypeptide comprising the amino acid sequence shown by SEQ ID NO: 2,
wherein the S38AA fragment is a polypeptide consisting of the S38AA extra-membranous domain or a partial polypeptide thereof,
wherein the antibody is an antibody specifically recognizing an amino acid region selected from the following (a) to (c): (a) the 689-1119th amino acids of the amino acid sequence shown by SEQ ID NO: 2, (b) the 399-688th amino acids of the amino acid sequence shown by SEQ ID NO: 2, and (c) an amino acid region spanning both regions (a) and (b), and
wherein the sample collected from the test person and the sample collected from the normal person are blood.