Compositions and methods for treatment on mammalian skin
Compositions useful for treatment of a wide range of skin disorders including: pre-cancerous lesions, keratotic lesions, superficial basal cell carcinomae; squamous cell carcinomae; malignant melanoma, and radiation-induced burns. In some embodiments the treatments comprise contacting human or other mammalian skin with a composition according to the disclosure. In other embodiments, administration of compositions provided is by injection. Some embodiments provide for preventive use of compositions provided towards preventing some forms of skin cancer and skin cancer-related disorders by repeated application to healthy-looking skin. Methods for providing the compositions are disclosed.
1 . Method for treating a condition in a mammalian subject, including aphthous ulcerations, gum papillae, mouth lesions, tissue flaps, inflammation of the gums, lacerations on the gums, wounds, and angular chelitis, which method comprises contacting a composition containing a hamelia patens extract to said disorder in an effective amount and frequency for reducing symptoms of said condition.
2 . Method according to claim 1 wherein said extract comprises an effective symptom-reducing amount of at least one material selected from the group consisting of: alkaloids, 2-alpha-hydroxyursolic acid, apigenin-7-o-beta d-glucuronide, aricine, catequine, 19-alphahydroxy Asiatic acid, 24-methylenecycloartane-3β-ol, 24-methylcycloart-24-en-3β-ol, 2 E-3,7,11,15,19-pentamethyl-2-eicosane-1-ol, ephedrine, flavonones, 2′-5-5′-7-tetrahydroxy-7-o-rutinoside, isomaruquine, isopteropodine, maruquine, the methyl ester of maruquine, mitraphylline, narirutin, narirutin (2r), narirutin (2s), oxindole alkaloids, oxindole aricine, palmirine, pigenin-7-o-beta D-glucuronide, pomolic acid, pteropodine, rumberine, rosmarinic acid, rotundic acid, rumberine, rutin, seneciophylline, β-sitosterol, speciophylline, stigmast-4-en-3-3-dione, stigmast-4-en-3-6-dione, stigmasterol, tannins, tormentic acid, uncarine F, and ursolic acid, and including any mixtures thereof.
3 . Method according to claim 2 wherein said composition comprises all of said materials recited in said group.
4 . Method according to claim 2 wherein each material selected to be present in said composition is independently present in any amount between 0.05% by weight and 30% by weight based on the total weight of said composition.
5 . Method according to claim 2 , wherein said composition is in any form selected from the group consisting of: salves, creams, ointments, colloidal suspensions, gels, and lotions.
6 . Method according to claim 8 wherein said carrier comprises an emulsion.
7 . Method according to claim 1 wherein said composition comprises any carrier selected from the group consisting of: water; saline solution, any C1 to C4 alcohol; any glyceryl ester oil; and any mineral oil.
8 . Method according to claim 1 wherein said composition comprises a nanoparticle.
9 . Method according to claim 8 wherein said nanoparticle is selected from the group consisting of: solid core nanoparticles, hollow core nanoparticles, lipid nanoparticles, PEG nanoparticles, and chitosan nanoparticles, including mixtures thereof.
10 . Method according to claim 1 wherein said composition comprises a liposome.
11 . Method according to claim 1 wherein said extract is an aqueous extract.
12 . Method according to claim 1 wherein said extract is a non-aqueous extract.
13 . Method according to claim 12 wherein said composition comprises a pharmaceutically-acceptable carrier.
14 . Method according to claim 13 wherein said contacting comprises a method selected from the group consisting of: injection of said composition into the basal layer of the dermis of a mammalian subject.