IP Library Granted Patent US 9,255,864
Granted Patent B2
US 9,255,864 · App. 14/001,895 · Granted Feb 9, 2016

Apparatus and method for processing a sample

Inventors: Wensheng Xia (Woodbury, MN); Jon A. Kirschhoffer (Stillwater, MN); Andrew W. Rabins (St. Paul, MN)
Assignee: 3M Innovative Properties Company
G01N1/34B01L3/5023B01L3/50255C12N15/1017B01L2300/0681B01L2300/0832B01L2300/0861B01L2400/049
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 9,255,864
App. No.
14/001,895
Granted
Feb 9, 2016
Kind
B2
Abstract

A first apparatus ( 100 ) for processing a liquid sample is disclosed. The apparatus ( 100 ) includes a sample-receiving ( 120 ), a filtrate-receiving component ( 150 ), and an analyte-capture element ( 170 ). The apparatus ( 100 ) forms a liquid flow path through which the sample passes, thereby causing the analyte-capture element ( 170 ) to capture an analyte, if present. A method is disclosed whereby a liquid sample is passed through the first ( 100 ) apparatus and the analyte-capture element ( 170 ) is easily separated from the apparatus for further processing and detection of the analyte. A structurally-related second apparatus ( 200 ) for processing a plurality of liquid samples, and a corresponding method of use, also is disclosed.

Claims (4)

1. A method of detecting the presence or absence of an analyte in a plurality of samples, comprising: providing a plurality of liquid samples and an apparatus, the apparatus comprising: a sample-receiving component; a filtrate-receiving component; and a plurality of analyte-capture elements; wherein the sample-receiving component comprises: a first body with first end, a second end, and a plurality of spaced-apart first chambers, each first chamber extending from the first end to the second end; wherein the first end comprises a plurality of first openings, at least one first opening configured to receive a sample; wherein the second end comprises a plurality of outlets, each outlet having a second opening; wherein the first body forms a plurality of fluid pathways, each pathway extending from a first opening to a second opening and through a first chamber there between; and a plurality of filter elements, each filter element disposed between the first and second openings in one of the plurality of first chambers; wherein the filtrate-receiving component comprises: a second body with a third end, a fourth end, and a plurality of spaced-apart second chambers, each second chamber extending from the third end to the fourth end and each second chamber comprising: a third opening at the third end, the third opening configured to receive one of the plurality of outlets; a fourth opening at the fourth end; wherein each of the plurality of analyte-capture elements is coupled to the filtrate-receiving component; wherein, when the sample-receiving component is coupled to the filtrate-receiving component, the apparatus forms a plurality of flow paths, each flow path facilitating fluid passage through one of the plurality of first chambers, one of the plurality of filter elements, and one of the plurality of second chambers, and facilitating fluid contact with at least one of the plurality of analyte-capture elements; wherein each of the plurality of outlets is shaped and proportioned to fit within and move longitudinally through at least a portion of the second chamber; passing at least two liquid sample through at least two of the plurality of filter elements to generate at least two filtered liquids; contacting the at least two filtered liquids with at least two analyte-capture elements; separating the at least two analyte-capture elements from the apparatus; and detecting the presence or absence of the analyte; wherein separating the at least two analyte-capture elements from the apparatus further comprises using at least two outlets to separate the at least two analyte-capture element from the apparatus; wherein using the at least two outlets further comprises urging the at least two outlets through the at least two second chambers to separate the at least two analyte-capture elements from the apparatus.

2. The method of claim 1 , further comprising attaching the apparatus to a source of negative pressure, wherein passing the plurality liquid samples through the at least two filter element further comprises using a negative pressure to draw the liquid samples through the at least two filter elements to produce at least two filtered samples.

3. The method of claim 2 , wherein using negative pressure to draw the plurality of samples through the at least two filter elements further comprises using the negative pressure to contact the filtered samples with the at least two analyte-capture elements.

4. The method of claim 1 further comprising, after separating the at least two analyte-capture elements, treating the at least two analyte capture element with a cell lysis agent.

Assignments (4)
SECURITY INTEREST Recorded Sep 2, 2022
From: NEOGEN CORPORATION; NEOGEN FOOD SAFETY US HOLDCO CORPORATION
To: JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT
Reel/Frame 061372/0264 →
PATENT ASSIGNMENT AGREEMENT Recorded Sep 1, 2022
From: 3M INNOVATIVE PROPERTIES COMPANY
To: GARDEN US HOLDCO CORPORATION
Reel/Frame 061365/0688 →
CHANGE OF NAME Recorded Sep 1, 2022
From: GARDEN US HOLDCO CORPORATION
To: NEOGEN FOOD SAFETY US HOLDCO CORPORATION
Reel/Frame 061370/0437 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 28, 2013
From: XIA, WENSHENG; KIRSCHHOFFER, JON A.; RABINS, ANDREW W.
To: 3M INNOVATIVE PROPERTIES COMPANY
Reel/Frame 031097/0367 →
Continuity (2)
Provisional Application 61451096 · Mar 9, 2011
Related Publication 20130344478A1 · Dec 26, 2013