Imidazole prodrug LXR modulators
View Patent ↗Imidazole prodrugs, pharmaceutically acceptable salts, or isomers thereof, of the invention are disclosed, which are useful as modulators of the activity of liver X receptors (LXR). Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
1. A compound, or pharmaceutically acceptable salt thereof, selected from the group consisting of:
2. A compound, or pharmaceutically acceptable salt thereof, of claim 1 which is
3. A compound, or pharmaceutically acceptable salt thereof, of claim 1 which is
4. A compound, or pharmaceutically acceptable salt thereof, which is
5. A compound, or pharmaceutically acceptable salt thereof, which is
6. The compound of claim 4 that is a pharmaceutically acceptable salt of said compound.
7. The compound of claim 6 , wherein the pharmaceutically acceptable salt comprises the di-(2-amino-2-(hydroxymethyl)propanediol)ethanolate salt.
8. A composition comprising at least one compound of claim 1 and one or more pharmaceutically acceptable carriers.
9. The composition of claim 8 further comprising at least one additional therapeutic agent.
10. A method of treating a disease or disorder comprising administering to a subject in need thereof a therapeutically effective amount of at least one compound of claim 1 , wherein the disease or disorder is atherosclerosis, dyslipidemia, diabetes.
11. The method of claim 10 wherein the disease or disorder is atherosclerosis.
12. The method of claim 10 wherein the disease or disorder is diabetes.
13. A composition comprising at least one compound of claim 4 and one or more pharmaceutically acceptable carriers.
14. The composition of claim 13 further comprising at least one additional therapeutic agent.