Compositions and methods for treatment of intracellular damage and bacterial infection
View Patent ↗Pre-implantation factor (PIF) may be used to treat intracellular damage. Aspects of the invention are directed to a method of treating intracellular damage comprising administering PIF to a subject in need thereof. Some aspects may be directed to methods of increasing cytokine secretion in response to intracellular damage comprising administering PIF to a subject in need thereof. The intracellular damage may be a result of a disease such as Listeria monocytogenes infection, malaria, Lyme disease, cardiovascular disease, duodenal peptic ulcer, atherosclerosis, peritonitis or tuberculosis. In some aspects, a method of treating tuberculosis is disclosed, comprising administering PIF to a subject in need thereof. In some aspects, a method of treating atherosclerosis is disclosed, comprising administering PIF to a subject in need thereof. In some aspects, a method of treating peritonitis is disclosed, comprising administering PIF to a subject in need thereof.
1. A method of therapeutically treating Mycobacterium tuberculosis infection comprising administering to a subject in need thereof a therapeutically effective amount of a PIF peptide comprising an amino acid sequence of SEQ ID NO: 3.
2. The method of claim 1 further comprising administering a potassium channel inhibitor.
3. The method of claim 2 , wherein the potassium channel inhibitor is a Kv1.3 inhibitor.
4. The method of claim 2 , wherein the potassium channel inhibitor is IFNγ.
5. The method of claim 1 , wherein the therapeutically effective amount is from about 0.01 to about 10 milligrams of PIF peptide per kilogram of subject.
6. A method of therapeutically treating tuberculosis comprising administering to a subject in need thereof a therapeutically effective amount of a PIF peptide comprising an amino acid sequence of SEQ ID NO: 3.
7. The method of claim 6 further comprising administering a potassium channel inhibitor.
8. The method of claim 7 , wherein the potassium channel inhibitor is a Kv1.3 inhibitor.
9. The method of claim 7 , wherein the potassium channel inhibitor is IFNγ.
10. A method of decreasing dissemination of tuberculosis bacteria comprising administering to a subject in need thereof a therapeutically effective amount of a PIF peptide comprising an amino acid sequence of SEQ ID NO: 3.
11. The method of claim 10 further comprising administering a potassium channel inhibitor.
12. The method of claim 11 , wherein the potassium channel inhibitor is a Kv1.3 inhibitor.
13. The method of claim 11 , wherein the potassium channel inhibitor is IFNγ.