IP Library Granted Patent US 9,179,995
Granted Patent B2
US 9,179,995 · App. 14/012,913 · Granted Nov 10, 2015

Methods of manufacturing slotted vascular treatment devices

Inventors: Vallabh Janardhan (Dallas, TX); Vikram Janardhan (Sacramento, CA)
Assignee: Insera Therapeutics, Inc.
A61F2/01A61B17/22A61B17/221A61B17/22031A61B17/22032A61B17/3207A61B17/32056A61B19/54A61F2/013A61M1/008A61M1/0031A61M25/0023A61M25/10A61M29/00B23K26/083B23K26/14B23K26/1405B23K26/1417B23K26/20B23K26/38B26F3/004D04C1/06D04C1/12A61B2017/00778A61B2017/22001A61B2017/22002A61B2017/22034A61B2017/22035A61B2017/22067A61F2002/011A61F2002/018A61M2025/0042A61M2202/06A61M2207/10A61M2210/12Y10T29/49913Y10T29/49995Y10T82/2521Y10T137/8376Y10T137/85954Y10T156/10
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Quick Facts
Patent No.
US 9,179,995
App. No.
14/012,913
Granted
Nov 10, 2015
Kind
B2
Abstract

Vascular treatment and methods include a plurality of self-expanding bulbs and a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Joints between woven structures and hypotubes include solder. Woven structures include patterns of radiopaque filaments measureable under x-ray. Structures are heat treated to include at least shapes at different temperatures. A catheter includes a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Heat treating systems include a detachable flange. Laser cutting systems include a fluid flow system.

Claims (42)

1. A method of manufacturing a vascular treatment device, the method comprising:

holding a hypotube using at least one bushing and at least one collet;

cutting a pattern comprising a plurality of kerfs into the hypotube, wherein cutting the pattern comprises:

directing a focused laser beam at the hypotube, the focused laser beam creating a heat impact puddle, the heat impact puddle being less than a width and a length of each of the plurality of kerfs, and

longitudinally and rotationally moving the hypotube in a design such that the focused laser beam cuts the hypotube to form the plurality of kerfs; and

during cutting the pattern, flowing fluid through the hypotube,

wherein holding the hypotube using the at least one bushing and the at least one collet comprises inhibiting motion of the hypotube prior to cutting of the hypotube by the focused laser beam and at least one of reducing sag of the hypotube and maintaining tension on the hypotube as the hypotube is advanced towards the focused laser beam, and wherein longitudinally and rotationally moving the hypotube comprises advancing the hypotube towards the focused laser beam using a hypotube dispenser comprising hypotube clamp and a motor.

2. The method of claim 1 , wherein directing the focused laser beam comprises creating the heat impact puddle inward of edges of the plurality of kerfs, and wherein cutting the pattern comprises cutting away the heat impact puddle.

3. The method of claim 1 , wherein directing the focused laser beam comprises creating the heat impact puddle at edges of the plurality of kerfs.

4. The method of claim 1 , wherein directing the focused laser beam comprises creating the heat impact puddle at corners of the plurality of kerfs.

5. The method of claim 1 , wherein the design comprises outlining edges of the plurality of kerfs.

6. The method of claim 1 , wherein the design comprises moving the hypotube comprises relatively moving the focused laser beam diagonal to the plurality of kerfs.

7. The method of claim 1 , wherein the design comprises a spiral.

8. The method of claim 1 , wherein holding the hypotube comprises adjusting a diameter of an aperture of the at least one collet.

9. The method of claim 1 , wherein flowing the fluid comprises adjusting a height of a reservoir containing the fluid.

10. The method of claim 1 , wherein flowing the fluid comprises adjusting a height of a water inlet gate between a reservoir containing the fluid and the hypotube.

11. The method of claim 1 , wherein the width of the kerfs is between about 0.02 mm and about 0.03 mm.

12. The method of claim 1 , wherein a ratio of the width of the kerfs to a circumferential thickness of struts at least partially defined by the kerfs is between about 1:1 and about 2:1.

13. A method of manufacturing a vascular treatment device, the method comprising:

cutting a pattern into a hypotube, wherein the pattern comprises:

a first pattern of longitudinally-spaced rows each comprising two kerfs and two stems, the two stems in each of the rows of the first pattern circumferentially 180° apart, the stems of the first pattern offset in a first circumferential direction, and

a second pattern of longitudinally-spaced rows each comprising two kerfs and two stems, the two stems in each of the rows of the second pattern circumferentially 180° apart, the rows of the second pattern interspersed with the rows of the first pattern, the stems of the second pattern offset in a second circumferential direction opposite the first circumferential direction; and

during cutting the pattern, flowing fluid through the hypotube.

14. The method of claim 13 , wherein each of the rows is angled with respect to a longitudinal axis of the hypotube.

15. The method of claim 13 , wherein the kerfs in each of the rows of the first pattern and the second pattern have rounded edges.

16. The method of claim 13 , wherein a pitch of the longitudinally-spaced rows of the first pattern and the second pattern varies longitudinally along the hypotube.

17. A method of manufacturing a vascular treatment device, the method comprising:

holding a hypotube using at least one bushing and at least one collet;

cutting a pattern comprising a plurality of kerfs into the hypotube, wherein cutting the pattern comprises:

directing a focused laser beam at the hypotube, the focused laser beam creating a heat impact puddle, the heat impact puddle being less than a width and a length of each of the plurality of kerfs, wherein a ratio of the width of the kerfs to a circumferential thickness of struts at least partially defined by the kerfs is between about 1:1 and about 2:1, and

longitudinally and rotationally moving the hypotube in a design such that the focused laser beam cuts the hypotube to form the plurality of kerfs; and

during cutting the pattern, flowing fluid through the hypotube.

18. The method of claim 17 , wherein directing the focused laser beam comprises creating the heat impact puddle inward of edges of the plurality of kerfs, and wherein cutting the pattern comprises cutting away the heat impact puddle.

19. The method of claim 17 , wherein directing the focused laser beam comprises creating the heat impact puddle at edges of the plurality of kerfs.

20. The method of claim 17 , wherein directing the focused laser beam comprises creating the heat impact puddle at corners of the plurality of kerfs.

21. The method of claim 17 , wherein the design comprises outlining edges of the plurality of kerfs.

22. The method of claim 17 , wherein the design comprises moving the hypotube comprises relatively moving the focused laser beam diagonal to the plurality of kerfs.

23. The method of claim 17 , wherein the design comprises a spiral.

24. The method of claim 17 , wherein holding the hypotube comprises adjusting a diameter of an aperture of the at least one collet.

25. The method of claim 17 , wherein flowing the fluid comprises adjusting a height of a reservoir containing the fluid.

26. The method of claim 17 , wherein flowing the fluid comprises adjusting a height of a water inlet gate between a reservoir containing the fluid and the hypotube.

27. The method of claim 17 , wherein the width of the kerfs is between about 0.02 mm and about 0.03 mm.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded Sep 9, 2021
From: KNOBBE, MARTENS, OLSON & BEAR, LLP
To: INSERA THERAPEUTICS, INC.
Reel/Frame 057454/0677 →
SECURITY INTEREST Recorded Jun 30, 2020
From: INSERA THERAPEUTICS, INC.
To: KNOBBE, MARTENS, OLSON & BEAR, LLP
Reel/Frame 053095/0350 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 3, 2013
From: JANARDHAN, VALLABH; JANARDHAN, VIKRAM
To: INSERA THERAPEUTICS, INC.
Reel/Frame 031125/0033 →
Continuity (4)
Continuation 13953540 · Jul 29, 2013
Continuation 13952982 · Jul 29, 2013
Provisional Application 61798540 · Mar 15, 2013
Related Publication 20140265030A1 · Sep 18, 2014