IP Library › Granted Patent US 8,956,658
Granted Patent B2
US 8,956,658 · App. 14/014,939 · Granted Feb 17, 2015

Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications

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Quick Facts
Patent No.
US 8,956,658
App. No.
14/014,939
Granted
Feb 17, 2015
Kind
B2
Abstract

The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.

Claims (6)

1. A nitric oxide-releasing particle comprising:

a co-condensed silica network comprising methylaminopropyl trimethoxysilane (MAP3) and tetraethyl orthosilicate (TEOS), wherein the MAP3 is distributed throughout the nitric oxide-releasing particle, and wherein the MAP3 comprises N-diazeniumdiolate functionalized MAP3.

2. The nitric oxide-releasing particle of claim 1 , wherein the MAP3 is present in a mol % of 10% to 75%.

3. The nitric oxide-releasing particle of claim 1 , wherein the MAP3 is present in a mol % of 1% to 90%.

4. The nitric oxide-releasing particle of claim 1 , wherein the MAP3 is present in a mol % of 45% to 55%.

5. The nitric oxide-releasing particle of claim 4 , wherein the MAP3 is present in a mol % of about 50%.

Assignments (4)
CORRECTION BY DECLARATION ERRONEOUSLY FILED AGAINST REEL 066350/FRAME 0942 Recorded Nov 12, 2024
From: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
To: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Reel/Frame 069386/0419 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 18, 2024
From: NOVAN, INC.
To: LNHC, INC.
Reel/Frame 066350/0942 →
CONFIRMATORY LICENSE Recorded Oct 28, 2013
From: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 031498/0921 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 5, 2013
From: SCHOENFISCH, MARK H.; SHIN, JAE HO; STASKO, NATHAN
To: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Reel/Frame 031141/0949 →