Granted Patent
B2
US 8,962,029 · App. 14/015,015 · Granted Feb 24, 2015
Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
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Abstract
The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.
Claims (4)
1. A nitric oxide-releasing particle comprising:
a co-condensed silica network comprising aminoethylaminopropyl trimethoxysilane (AEAP3) and tetraethyl orthosilicate (TEOS), wherein the AEAP3 is distributed throughout the nitric oxide-releasing particle, and wherein the AEAP3 comprises N-diazeniumdiolate functionalized AEAP3.
2. The nitric oxide-releasing particle of claim 1 , wherein the AEAP3 is present in a mol % of 1% to 90%.
3. The nitric oxide-releasing particle of claim 1 or claim 2 , wherein the AEAP3 is present in a mol % of about 50%.
Assignments (4)
CORRECTION BY DECLARATION ERRONEOUSLY FILED AGAINST REEL 066350/FRAME 0942
Recorded Nov 12, 2024
From: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
To: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Reel/Frame 069386/0419 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 18, 2024
From: NOVAN, INC.
To: LNHC, INC.
Reel/Frame 066350/0942 →
CONFIRMATORY LICENSE
Recorded Oct 28, 2013
From: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 031498/0923 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Sep 5, 2013
From: SCHOENFISCH, MARK H.; SHIN, JAE HO; STASKO, NATHAN
To: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Reel/Frame 031141/0747 →