Composition and methods for modulating a kinase cascade
The invention relates to compounds and methods for modulating one or more components of a kinase cascade. The invention also relates to substantially pure compound 1 and substantially pure compound 1 salt (e.g., compound 1 hydrochloride salt and compound 1 benzenesulfonate salt). The invention further relates to methods of preparing substantially pure compound 1 and compound 1 salts.
1. A composition comprising a benzenesulfonate salt of compound 1:
or a pharmaceutically acceptable solvate or hydrate thereof, wherein the benzenesulfonate salt of compound 1 has a purity greater than 98.0% as determined by HPLC.
2. The composition of claim 1 , further comprising a pharmaceutically acceptable carrier or excipient.
3. The composition of claim 1 , wherein compound 1 has a purity of 98.5% as determined by HPLC.
4. The composition of claim 1 , wherein compound 1 has a purity of 99.0% as determined by HPLC.
5. The composition of claim 1 , wherein compound 1 has a purity of 99.5% as determined by HPLC.
6. The composition of claim 1 , wherein compound 1 has a purity of 99.6% as determined by HPLC.
7. The composition of claim 1 , wherein compound 1 has a purity of 99.7% as determined by HPLC.
8. The composition of claim 1 , wherein compound 1 has a purity of 99.8% as determined by HPLC.
9. The composition of claim 1 , wherein compound 1 has a purity of 99.9% as determined by HPLC.
10. The composition of claim 1 , wherein compound 1 contains less than 250 ppm ethyl chloride.