7-deazapurine modulators of histone methyltransferase, and methods of use thereof
View Patent ↗Disclosed are compounds, pharmaceutical compositions containing the compounds, uses of the compounds and compositions as modulators of histone methyltransferases, and methods for treating diseases influenced by modulation of histone methyltransferase activity.
1. A compound selected from
and pharmaceutically acceptable salts, hydrates, enantiomers and stereoisomers thereof.
2. A compound
3. A pharmaceutically acceptable salt of
4. The pharmaceutically acceptable salt of claim 3 , being
5. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable diluent or carrier.
6. A pharmaceutical composition comprising a compound of claim 2 and a pharmaceutically acceptable diluent or carrier.
7. A pharmaceutical composition comprising a pharmaceutically acceptable salt of claim 3 and a pharmaceutically acceptable diluent or carrier.
8. A pharmaceutical composition comprising a pharmaceutically acceptable salt of claim 4 and a pharmaceutically acceptable diluent or carrier.
9. A kit comprising a compound of claim 1 and instructions for use thereof.
10. A kit comprising a compound of claim 2 and instructions for use thereof.
11. A kit comprising a pharmaceutically acceptable salt of claim 3 and instructions for use thereof.
12. A kit comprising a pharmaceutically acceptable salt of claim 4 and instructions for use thereof.