Oligomer-tricyclic conjugates
View Patent ↗The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water-soluble oligomer.
1. A method of treatment, comprising administering a stable conjugate selected from:
wherein n is an integer from 1 to 30, to a patient in need thereof;
wherein the compound is administered for sedative, hypnotic, anti-anxiety, tranquilizing, anti convulsant, muscle relaxant, anti-depressant, or analgesic effect.
2. The method of claim 1 , wherein n is an integer from 1 to 10.
3. The method of claim 2 , wherein the stable conjugate has the structure:
4. The method of claim 3 , wherein n is 3, 5, 6, or 7.
5. The method of claim 2 , wherein the stable conjugate has the structure:
6. The method of claim 1 , wherein the stable conjugate is administered to treat pain.
7. The method of claim 6 , wherein the stable conjugate is administered to treat neuropathic pain.
8. The method of claim 6 , wherein the stable conjugate is administered to treat visceral pain.
9. A method of claim 1 , wherein the stable conjugate is administered as a pharmaceutical composition comprising the stable conjugate, and optionally, a pharmaceutically acceptable excipient.
10. The method of claim 9 , wherein the pharmaceutical composition is suitable for oral administration.
11. The method of claim 1 , wherein the stable conjugate is administered as a unit dosage form.