IP Library › Granted Patent US 8,884,019
Granted Patent B2
US 8,884,019 · App. 14/020,286 · Granted Nov 11, 2014

Benzimidazole compound crystal

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Quick Facts
Patent No.
US 8,884,019
App. No.
14/020,286
Granted
Nov 11, 2014
Kind
B2
Abstract

A novel crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole or a salt thereof of the present invention is useful for an excellent antiulcer agent.

Claims (7)

1. A method for producing an amorphous of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole or salt thereof, which comprises:

subjecting a racemate of a compound of 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole to an optical resolution so that an R-enantiomer of the compound is obtained;

adding a solvent comprising ethanol to the obtained R-enantiomer of the compound so that the R-enantiomer of the compound dissolves in the solvent and an R-enantiomer solution is formed;

optionally concentrating the R-enantiomer solution so as to form a concentrate;

further adding hexane to the R-enantiomer solution or the concentrate; and

evaporating the resulting solution to dryness.

2. A method according to claim 1 , wherein the optical resolution is carried out by using a chiral column.