Implantable systems and methods for identifying a contra-ictal condition in a subject
View Patent ↗Systems and methods of monitoring a subject's neurological condition are provided. In some embodiments, the method includes the steps of analyzing a physiological signal (such as an EEG) from a subject to determine if the subject is in a contra-ictal condition; and if the subject is in a contra-ictal condition, providing an indication (e.g., to the subject and/or to a caregiver) that the subject is in the contra-ictal condition. The systems and methods may utilize a minimally invasive, leadless device to monitor the subject's condition. In some embodiments, if the subject is in a pro-ictal condition, the method includes the step of providing an indication (such as a red light) that the subject is in the pro-ictal condition.
1. A physiological monitoring system comprising:
an electrode configured to detect a physiological signal from a subject;
a processing assembly for sampling the physiological signal, the processing assembly being configured to process the physiological signal to determine whether the subject is in a contra-ictal state and generate an output indicating the determination, said contra-ictal state being a neurological state in which the subject is unlikely to transition into an ictal state within a time period; and
a therapy device that receives the output and selectively applies therapy in response to the output.
2. The physiological monitoring system of claim 1 , further comprising:
a user interface configured to provide an output to the subject regarding the contra-ictal state of the subject.
3. The physiological monitoring system of claim 1 , the processing assembly being further configured to process the physiological signal to determine whether the subject transitions into or from the contra-ictal state.
4. The physiological monitoring system of claim 1 , the processing assembly being further configured to process the physiological signal to determine whether the subject transitions from the contra-ictal state to an inter-ictal state different than the contra-ictal state.
5. The physiological monitoring system of claim 1 , the processing assembly being further configured to process the physiological signal to determine whether the subject transitions from the contra-ictal state to the ictal state.
6. The physiological monitoring system of claim 1 , wherein the processing assembly is adapted to determine if the subject is in a contra-ictal condition by:
extracting N features from the sampled physiological signal;
generating an N-dimensional feature vector of the extracted N features for time points of the sampled physiological signal; and
determining if the N-dimensional feature vector is within a contra-ictal cluster or region in an N-dimensional space.
7. The physiological monitoring system of claim 1 , wherein the physiological signal is at least one of an EEG signal, a heart rate signal, and a respiratory signal.
8. The physiological monitoring system of claim 1 , wherein the physiological signal corresponds to at least one of a blood pressure, a blood oxygenation, a temperature, a blood flow, an ECG, an EKG, a chemical concentration of a neurotransmitter, a chemical concentration of a medication, and a pH in the blood.
9. The physiological monitoring system of claim 1 , wherein the electrode is configured to detect the physiological signal through the skin of the subject.
10. The physiological monitoring system of claim 1 , wherein the therapy device comprises an implanted stimulator.
11. A method of monitoring physiological signals from a subject, said method comprising:
detecting a physiological signal from the subject with an electrode;
analyzing the physiological signal from the subject using a processor to determine whether the subject is in a contra-ictal state and generate an output indicating the determination, said contra-ictal state being a neurological state in which the subject is unlikely to transition into an ictal state within a time period; and
selectively applying therapy in response to the output using a therapy device.
12. The method of claim 11 , further comprising:
reporting an output to the subject regarding the contra-ictal state of the subject.
13. The method of claim 11 , further comprising:
analyzing the physiological signal to determine whether the subject transitions into or from the contra-ictal state.
14. The method of claim 11 , further comprising:
analyzing the physiological signal to determine whether the subject transitions from the contra-ictal state to an inter-ictal state different than the contra-ictal state.
15. The method of claim 11 , further comprising:
analyzing the physiological signal to determine whether the subject transitions from the contra-ictal state to the ictal state.
16. The method of claim 11 , wherein the analyzing the physiological signal comprises:
extracting N features from the sampled physiological signal;
generating an N-dimensional feature vector of the extracted N features for time points of the sampled physiological signal; and
determining if the N-dimensional feature vector is within a contra-ictal cluster or region in an N-dimensional space.
17. The method of claim 11 , wherein the physiological signal is at least one of an EEG signal, a heart rate signal, and a respiratory signal.
18. The method of claim 11 , wherein the physiological signal corresponds to at least one of a blood pressure, a blood oxygenation, a temperature, a blood flow, an ECG, an EKG, a chemical concentration of a neurotransmitter, a chemical concentration of a medication, and a pH in the blood.
19. The method of claim 11 , wherein the electrode is configured to detect the physiological signal through the skin of the subject.
20. The method of claim 11 , wherein selectively applying therapy in response to the output using a therapy device comprises applying the therapy using an implanted stimulator.
21. A physiological monitoring system comprising:
an electrode configured to detect a physiological signal from a subject;
a processing assembly for sampling the physiological signal, the processing assembly being configured to process the physiological signal to determine whether the subject is in a contra-ictal state and generate an output indicating the determination, said contra-ictal state being a neurological state in which the subject is unlikely to transition into an ictal state within a time period;
a therapy device that receives the output and selectively applies therapy in response to the output; and
a user interface in communication with the processing assembly, the user interface generating an output based on the physiological signal, the output indicating whether the subject is in a contra-ictal state.
22. The physiological monitoring system of claim 21 , the output further indicating at least one of whether the subject transitions into the contra-ictal state, the subject transitions from the contra-ictal state, the subject transitions from the contra-ictal state to an inter-ictal state different than the contra-ictal state, and the subject transitions from the contra-ictal state to the ictal state.
23. The physiological monitoring system of claim 21 , wherein the therapy device comprises an implanted stimulator.