Multi-encapsulated microspheres made with oxidized cellulose for in-situ reactions
View Patent ↗A microsphere and methods for forming the same are disclosed. The microsphere includes modified cellulose and at least one first microsphere disposed within a multi-encapsulating microsphere, the at least one first microsphere comprising at least one first hydrogel precursor; and at least one second microsphere disposed within the multi-encapsulating microsphere, the at least one second microsphere comprising at least one second hydrogel precursor cross-linkable with the at least one first hydrogel precursor upon degradation of the at least one first microsphere and the at least one second microsphere.
1. A multi-encapsulating microsphere comprising:
modified cellulose;
at least one first microsphere disposed within the multi-encapsulating microsphere, the at least one first microsphere comprising at least one first hydrogel precursor; and
at least one second microsphere disposed within the multi-encapsulating microsphere, the at least one second microsphere comprising at least one second hydrogel precursor cross-linkable with the at least one first hydrogel precursor upon degradation of the at least one first microsphere and the at least one second microsphere.
2. The multi-encapsulating microsphere according to claim 1 , wherein the at least one first hydrogel precursor comprises at least one electrophilic functional group.
3. The multi-encapsulating microsphere according to claim 2 , wherein the at least one electrophilic functional group is selected from the group consisting of N-hydroxysuccinimides, sulfosuccinimides, and combinations thereof.
4. The multi-encapsulating microsphere according to claim 1 , wherein the at least one second hydrogel precursor comprises at least one nucleophilic functional group.
5. The multi-encapsulating microsphere according to claim 4 , wherein the at least one nucleophilic functional group is selected from the group consisting of amines, thiols, and combinations thereof.
6. The multi-encapsulating microsphere according to claim 1 , further comprising:
at least one third microsphere disposed within the multi-encapsulating microsphere, the at least one third microsphere encapsulating the at least one second microsphere.