Silicone gel-based compositions for wound healing and scar reduction
View Patent ↗This invention is a composition comprising a cyclic siloxane, a silicone occlusive fluid, a silicone occlusive gel, and a silicone resin powder. The composition is useful for wound healing.
1. A method for the treatment of wounds to reduce scarring comprising administering to a patient in need thereof an effective amount of a composition comprising:
a cyclic siloxane selected from the group consisting of cyclotetrasiloxane (octamethylcyclotetrasiloxane), cyclopentasiloxane (decamethylcyclopentasiloxane), cyclohexasiloxane (dodecamethylcyclohexasiloxane), and mixtures thereof;
a poly(dimethylsiloxane) having a viscosity between 100 cSt and 350 cSt;
a silicone gel in the form of a dispersion of a silicone elastomer in a silicone oil, wherein the silicone elastomer is selected from the group consisting of polysilicone-11, cetearyl dimethicone/vinyl dimethicone crosspolymer, dimethicone/phenyl vinyl dimethicone crosspolymer, and dimethicone/vinyl dimethicone crosspolymer, and wherein the silicone oil is selected from the group consisting of phenyl trimethicone and phenyl dimethicone;
a polymethylsilsesquioxane powder; and
a tetra(C 8 -C 24 acyl)ascorbic acid ester or salt thereof;
wherein
the concentration of the cyclic siloxane is between 55% and 65% by weight of the composition;
the concentration of the poly(dimethylsiloxane) is between 3% and 7% by weight of the composition; and
the concentration of the silicone gel is between 30% and 40% by weight of the composition.
2. The method of claim 1 , wherein the poly(dimethylsiloxane) has a viscosity of 200 cSt.
3. The method of claim 1 , wherein the cyclic siloxane is cyclopentasiloxane.
4. The method of claim 3 , wherein the silicone elastomer is polysilicone-11 and the silicone oil is phenyl trimethicone.
5. The method of claim 4 , wherein the poly(dimethylsiloxane) has a viscosity of 200 cSt.
6. The method of claim 1 , wherein the concentration of ascorbic acid tetraisopalmitate is between 0.3% and 0.7% by weight of the composition.
7. A method for the treatment of wounds to reduce scarring comprising administering to a patient in need thereof an effective amount of a composition comprising:
cyclopentasiloxane;
a poly(dimethylsiloxane) having a viscosity between 100 cSt and 350 cSt;
a silicone gel in the form of a dispersion of a silicone elastomer in a silicone oil, wherein the silicone elastomer is polysilicone-11 and the silicone oil is phenyl trimethicone;
a polymethylsilsesquioxane powder; and
a tetra(C 8 -C 24 acyl)ascorbic acid ester or salt thereof;
wherein
the concentration of cyclopentasiloxane is between 55% and 65% by weight of the composition;
the concentration of the poly(dimethylsiloxane) is between 2% and 10% by weight of the composition;
the concentration of the silicone gel is between 30% and 40% by weight of the composition; and
the concentration of ascorbic acid tetraisopalmitate is between 0.1% and 2% by weight of the composition.
8. The method of claim 7 , wherein the polymethylsilsesquioxane powder has an average particle size of 4-8 micrometers.
9. The method of claim 7 , wherein the concentration of the polymethylsilsesquioxane powder is between 1% and 5% by weight of the composition.
10. The method of claim 8 , wherein the concentration of the polymethylsilsesquioxane powder is between 2% and 3% by weight of the composition.
11. The method of claim 8 , wherein the concentration of the poly(dimethylsiloxane) is between 3% and 7% by weight of the composition.
12. The method of claim 10 , wherein the concentration of the poly(dimethylsiloxane) is between 3% and 7% by weight of the composition.
13. The method of claim 12 , wherein the poly(dimethylsiloxane) has a viscosity of 200 cSt.
14. The method of claim 10 , wherein the concentration of ascorbic acid tetraisopalmitate is between 0.3% and 0.7% by weight of the composition.
15. The method of claim 12 , wherein the concentration of ascorbic acid tetraisopalmitate is between 0.3% and 0.7% by weight of the composition.
16. The method of claim 1 , wherein the tetra(C 8 -C 24 acyl)ascorbic acid ester or salt thereof is ascorbic acid tetraisopalmitate.
17. The method of claim 7 , wherein the tetra(C 8 -C 24 acyl)ascorbic acid ester or salt thereof is ascorbic acid tetraisopalmitate.