Selective lung tissue ablation
View Patent ↗Medical methods and systems are provided for effecting lung volume reduction by selectively ablating segments of lung tissue.
1. A treatment system for ablating a targeted treatment site in a lung of a patient, comprising:
a shaft having a proximal end and a distal end;
an energy emitting element disposed near the distal end of the shaft, wherein the energy-emitting element is configured to extend through and conform to an airway in the targeted treatment site of the lung;
one or more electronic temperature sensors; and
one or more isolation catheters configured to deliver cooling media to neighboring lung tissue of the targeted treatment site of the lung;
wherein said sensors are connected to a feedback control system configured to control the pressure and temperature simultaneously between the targeted treatment site versus the neighboring lung tissue to selectively ablate lung tissue.
2. A treatment apparatus as in claim 1 , wherein the energy emitting element comprises an elongate coil shaped electrode.
3. A treatment apparatus as in claim 1 , wherein the energy emitting element comprises an elongate braided wire electrode.
4. A treatment apparatus as in claim 1 , wherein the energy-emitting element includes an expansion element which expands the energy emitting element to conform to a shape of the airway of the treatment site.
5. A treatment apparatus as in claim 4 , wherein the expansion element comprises an inflatable balloon.
6. A treatment apparatus as in claim 4 , wherein the expansion element comprises a constraint which can be released to allow the expansion element to self-expand.
7. A treatment apparatus as in claim 1 , wherein the energy emitting element comprises au electrically resistive coil or a hot fluid element.
8. A method for selectively ablating a treatment region in a lung comprising:
advancing a treatment apparatus through an airway toward the treatment region in the lung;
exchanging energy through the treatment apparatus to heat or cool the treatment region to a level which destroys tissue at the region; and
protecting adjacent regions in the lung and surrounding tissue from thermal damage by controlling pressure or temperature at the treatment region and at one or more untreated regions adjacent the treatment region.
9. A method as in claim 8 , wherein the tissue is raised to a temperature in the range from 40° C. to 95° C.
10. A method as in claim 8 , wherein the delivered energy comprises radiofrequency, alternating current, microwave, ultrasound, coherent light, incoherent light, radioisotopes, or a combination thereof.
11. A method as in claim 8 , further comprising advancing at least one additional treatment apparatus toward the treatment site in the lung region and delivering energy to the treatment site through at least two treatment apparatuses.
12. A method as in claim 8 , further comprising ventilating the patient's other lung.
13. A method as in claim 12 , further comprising ventilating untreated region(s) of the lung adjacent to the treated region.
14. A method as in claim 8 , further comprising collapsing the lung containing the lung under treatment prior to heating a treatment site.
15. A method as in claim 8 , further comprising controlling pressure and temperature simultaneously in the treatment site and in the one or more untreated regions adjacent the treatment site so that thermal damage to the non-targeted sites is minimized.
16. A method as in claim 8 , further comprising introducing an electrically or thermally conducting fluid into the treatment site to improve energy distribution.
17. A method as in claim 16 , further comprising deploying isolation barriers to inhibit the conductive fluid from migrating from the treatment site.
18. A method as in claim 8 , wherein the treatment site comprises an entire lobe of the lung.
19. A method as in claim 8 , further comprising monitoring the temperature within the treatment site and controlling the energy exchange to maintain a temperature within a desired range.
20. A method as in claim 8 , further comprising:
testing the patient to determine if the treatment site is subject to collateral ventilation; and
ablating the treatment site only if the treatment site is subject to collateral ventilation.