Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
View Patent ↗Complexes of heterocyclic radionuclides are prepared based upon ligands having substituted pyridyl and imidazolyl groups. The ligands are bifunctional, having amino acid residues that may act as a linker to a bioactive molecu le, and a tridentate chelator that may complex the radionuclide. The bioactive molecule may be a peptide or somatostatin.
1. A compound represented by:
a pharmaceutically acceptable salt thereof;
f is an integer from 0 to 12; and
g is an integer from 0 to 12.
2. The compound of claim 1 , wherein f is 2 to 10.
3. The compound of claim 1 , wherein f is 4.
4. The compound of claim 1 , wherein g is 2 to 10.
5. The compound of claim 1 , wherein g is 4.
6. The compound of claim 1 , wherein the compound is:
or
a pharmaceutically acceptable salt thereof.
7. The compound of claim 6 , wherein f is 4.
8. The compound of claim 1 , wherein the compound is:
or
a pharmaceutically acceptable salt thereof.
9. The compound of claim 8 , wherein g is 4.
10. The compound of claim 1 , wherein the compound is:
or
a pharmaceutically acceptable salt thereof.
11. The compound of claim 10 , wherein g is 4.
12. The compound of claim 1 , wherein the compound is:
or
a pharmaceutically acceptable salt thereof.
13. The compound of claim 12 , wherein f is 4.
14. A method of preparing a peptide conjugate incorporating a compound, the method comprising synthesizing the peptide conjugate using solid-phase peptide-synthesis techniques;
wherein:
the compound is:
a pharmaceutically acceptable salt thereof;
f is an integer from 0 to 12; and
g is an integer from 0 to 12.
15. The method of claim 14 , wherein f is 2 to 10.
16. The method of claim 14 , wherein f is 4.
17. The method of claim 14 , wherein g is 2 to 10.
18. The method of claim 14 , wherein g is 4.
19. The method of claim 14 , wherein the compound is:
or
a pharmaceutically acceptable salt thereof.
20. The method of claim 19 , wherein f is 4.
21. The method of claim 14 , wherein the compound is:
or
a pharmaceutically acceptable salt thereof.
22. The method of claim 21 , wherein g is 4.
23. The method of claim 14 , wherein the compound is:
or
a pharmaceutically acceptable salt thereof.
24. The method of claim 23 , wherein g is 4.
25. The method of claim 14 , wherein the compound is:
or
a pharmaceutically acceptable salt thereof.
26. The method of claim 25 , wherein f is 4.