Systems and methods for spectroscopic measurement of a characteristic of biological tissue
View Patent ↗A method and system for spectroscopic measurement of a characteristic of a biological tissue is provided. The method includes the steps of: (1) using at least one light source to emit light that penetrates the biological tissue; (2) using at least one light detector to detect light emitted by the at least one light source and passed through the biological tissue, and to convert the detected light into a detection signal, the detection signal including an unwanted noise component; and (3) using a processor to process the detection signal and to determine an adjusted peak-to-peak amplitude value that is representative of an amplitude of the detection signal adjusted for the unwanted noise component.
1. A system for spectroscopic measurement of a characteristic of a biological tissue, the system comprising:
at least one light source operable to emit light that penetrates the biological tissue;
at least one light detector operable to detect light emitted by the at least one light source and passed through the biological tissue, and operable to convert the detected light into a detection signal; and
a processor operable to receive the detection signal, and operable to determine an adjusted peak-to-peak amplitude value that is representative of an amplitude of the detection signal adjusted to account for an unwanted noise component present in the detection signal,
wherein the processor includes a detector circuit, the detector circuit comprising:
a differentiating amplifier operable to receive the detection signal, and operable to convert the detection signal into a differentiated detection signal;
an adjustable gain amplifier operable to receive the differentiated detection signal, and operable to convert the differentiated detection signal into a differentiated and gain-adjusted detection signal;
a positive peak detector operable to receive the differentiated and gain-adjusted detection signal, and operable to determine a maximum value of the differentiated and gain-adjusted detection signal; and
a negative peak detector operable to receive the differentiated and gain-adjusted detection signal, and operable to determine a minimum value of the differentiated and gain-adjusted detection signal.
2. The system of claim 1 , the detector circuit comprising:
a difference amplifier operable to determine the adjusted peak-to-peak amplitude value using the maximum value received from the positive peak detector and the minimum value received from the negative peak detector; and
a sample and hold device operable to receive and hold the adjusted peak-to-peak amplitude value.
3. The system of claim 1 , wherein the characteristic of the biological tissue is selected from the group consisting of: oxygen saturation, hemoglobin concentration, and melanin concentration.
4. The system of claim 1 , wherein the processor is operable to determine the adjusted peak-to-peak amplitude value using the maximum value and the minimum value.
5. A method for spectroscopic measurement of a characteristic of a biological tissue, the method comprising the steps of:
using at least one light source to emit light that penetrates the biological tissue;
using at least one light detector to detect light emitted by the at least one light source and passed through the biological tissue, and to convert the detected light into a detection signal, the detection signal including an unwanted noise component; and
using a processor to process the detection signal and to determine an adjusted peak-to-peak amplitude value that is representative of an amplitude of the detection signal adjusted for the unwanted noise component present within the detection signal,
wherein the processor includes a detector circuit, the detector circuit comprising:
a differentiating amplifier that receives the detection signal and converts the detection signal into a differentiated detection signal;
an adjustable gain amplifier that receives the differentiated detection signal and converts the differentiated detection signal into a differentiated and gain-adjusted detection signal;
a positive peak detector that receives the differentiated and gain-adjusted detection signal and determines a maximum value of the differentiated and gain-adjusted detection signal; and
a negative peak detector that receives the differentiated and gain-adjusted detection signal and determines a minimum value of the differentiated and gain-adjusted detection signal.
6. The method of claim 5 , wherein the characteristic of the biological tissue is selected from the group consisting of: oxygen saturation, hemoglobin concentration, and melanin concentration.
7. The method of claim 5 , wherein the step of using the processor to process the detection signal and to determine the adjusted peak-to-peak amplitude value includes determining the adjusted peak-to-peak amplitude value using the maximum value and the minimum value.