IP Library › Granted Patent US 9,249,144
Granted Patent B2
US 9,249,144 · App. 14/043,210 · Granted Feb 2, 2016

Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds

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Quick Facts
Patent No.
US 9,249,144
App. No.
14/043,210
Granted
Feb 2, 2016
Kind
B2
Abstract

This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.

Claims (10)

1. A compound of the following formulae:

2. The compound of claim 1 , having a structure according to the following formula,

3. The compound of claim 1 , having a structure according to the following formula,

4. The compound of claim 1 , having a structure according to the following formula,

or a salt thereof.

5. The compound of claim 1 , having a structure according to the following formula,

6. The compound of claim 1 , having a structure according to the following formula,

or a salt thereof.

7. The compound of claim 1 , having a structure according to the following formula,

or a salt thereof.

Assignments (5)
RELEASE OF INTELLECTUAL PROPERTY SECURITY AGREEMENTS AT R/F 41939/0487, 46591/0544 AND 53940/0001 Recorded Apr 15, 2026
From: MIDCAP FINANCIAL TRUST
To: TERSERA THERAPEUTICS LLC,
Reel/Frame 075420/0453 →
RELEASE OF SECURITY INTEREST Recorded Apr 4, 2023
From: MIDCAP FINANCIAL TRUST, AS AGENT
To: TERSERA THERAPEUTICS LLC
Reel/Frame 063253/0942 →
FIRST LIEN PATENT SECURITY AGREEMENT Recorded Jul 19, 2018
From: TERSERA THERAPEUTICS LLC
To: MIDCAP FINANCIAL TRUST, AS AGENT
Reel/Frame 046591/0544 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 7, 2016
From: SCHERING CORPORATION
To: OPKO HEALTH, INC.
Reel/Frame 037433/0239 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 7, 2016
From: WU, GEORGE G.; FU, XIAOYONG; ORR, ROBERT K.; CHEN, FRANK XING; SPRAGUE, VICTORIA M.; XIE, JI; ZENG, LIANSHENG; POIRIER, MARC; MERGELSBERG, INGRID; ZHANG, FUCHENG; WERNE, GERALD; CHEN, YUYIN; CASTELLANOS, LOUIS PETER; CUI, JIAN
To: SCHERING CORPORATION
Reel/Frame 037459/0372 →